Results 21 to 30 of about 26,991 (212)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Developing a Model for Iran’s Military Export Pathology (Case: One of the Iranian Military Holding Corporations) [PDF]

مطالعات مدیریت بهبود و تحول, 2011
One of the most important strategic sectors of any country's economyis the military sector.Thus governments allocate a considerable amount of effort and cost to helpthis sector through obtaining its objectives. Meanwhile, it is known that aneffective way
Gholamreza Tavakoli, Mehdi Elyasi, Maysam Shafiee Roodposhti, Aliasghar Heidari   +3 more
doaj  

Comprehending Incomprehensible: Comparative Approach in Qualitative Psychological Studies of Religiosity

Культурно-историческая психология, 2021
The article presents an analysis of methodological problems in psychological studies of religiosity and offers a new comparative approach to qualitative research of religiosity as a component of human life.
Bratus B.S., Busygina N.P., Krichevec A.N., Nasibullov K.I.   +3 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Impact of Neighborhood Factors on Heart Failure Outcomes

JACC: Advances
Background: Few studies have examined the impact of neighborhood-level factors on outcomes for patients with heart failure with reduced ejection fraction (HFrEF).
Timothy Bober, MD, MS, Emily N. Guhl, MD, Scott Rothenberger, PhD, Kwonho Jeong, MS, Kaleab Z. Abebe, PhD, Julia Holber, MD, Amy M. Anderson, MS, LPC, Jared W. Magnani, MD, MSc, Amber E. Johnson, MD, MS, MBA, Bruce L. Rollman, MD, MPH, MBA   +9 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

An 11-Year (2012–2022) review of Journal of Athletic Training publication study designs and sample sizes

BMC Medical Research Methodology
Background Research findings must be representative by creating a sample of individuals, ensuring the results can be generalized and applicable to a larger population, which has historically been guided by a power analysis.
Zachary K. Winkelmann, Samantha E. Scarneo-Miller, Emily C. Smith, Ryan M. Argetsinger, Lindsey E. Eberman   +4 more
doaj   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Eating Animals to Build Rapport: Conducting Research as Vegans or Vegetarians

Societies, 2014
Notions of hospitality, community, and the fostering of rapport and connection are foundational concerns for conducting research across difference. Drawing on methodological literature, this paper considers how access to various communities and “good ...
Katie MacDonald, Kelly Struthers Montford   +1 more
doaj   +1 more source