Results 41 to 50 of about 23,907,843 (383)

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Fear and Safety: Students use qualitiative methods to explore the meaning of fear and safety among the University of Pennsylvania community [PDF]

, 2015
Each student in the Qualitative Methods Research Class (SW781), Spring 2015, recruited a study participant (n=25) (undergraduate students, graduate students, staff, and faculty from across the University) and trained them in the appropriate and ethical ...
SWRK 781: Qualitative Research
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Wearables in sociodrama: An embodied mixed-methods study of expressiveness in social interactions

Wearable Technologies, 2022
This mixed-methods study investigates the use of wearable technology in embodied psychology research and explores the potential of incorporating bio-signals to focus on the bodily impact of the social experience.
Katerina El-Raheb, Vilelmini Kalampratsidou, Philia Issari, Eugenie Georgaca, Flora Koliouli, Evangelia Karydi, Theodora (Dora) Skali, Pandelis Diamantides, Yannis Ioannidis   +8 more
doaj   +1 more source

Methods for the thematic synthesis of qualitative research in systematic reviews [PDF]

, 2007
Background There is a growing recognition of the value of synthesising qualitative research in the evidence base in order to facilitate effective and appropriate health care.
A Bryman, A Cobb, A Daly, A Harden, A Harden, A Harden, A Harden, A Harden, A Oakley, A Oakley, Angela Harden, B Paterson, C Marston, C Mulrow, C Seale, EPPI-Centre, GW Noblit, H Cooper, H White, I Chalmers, I Chalmers, J Barroso, J Popay, J Popay, J Shepherd, J Thomas, J Thomas, J Thomas, J Thomas, James Thomas, K Strike, L Spencer, LA Walters, LH Doyle, M Boulton, M Dixon-Woods, M Dixon-Woods, M Dixon-Woods, M Egger, M Fisher, M Hammersley, M Newman, M Petticrew, M Sandelowski, M Sandelowski, M Sandelowski, Medical Sociology Group, N Britten, N Mays, P Alderson, P Davies, P Juni, R Campbell, R Dixey, R Rees, RE Boyatzis, S Thorne, SSL Wong, V Braun   +58 more
core   +8 more sources

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Psychological meanings reported by patients with Graves’ Disease in hyperthyroidism but without ophthalmopathy about their quotidian life: A qualitative study conducted in a Brazilian university specialized outpatient service

European Psychiatry
Introduction To handle well clinical treatments, it is crucial to know the expectations of patients who seek help. We need to ask ourselves: how do patients interpret subjectively their diagnosis, treatments, and self-care?
L. S. Valladão, F. S. Silva, C. F. Casagrande, L. M. Guerra, D. E. Zantut-Wittmann, E. R. Turato   +5 more
doaj   +1 more source

‘Staying alive’ with antiretroviral therapy: a grounded theory study of people living with HIV in Peru

BMJ Global Health, 2021
Background To achieve an optimal quality of life through chronic disease management, people living with HIV (PLHIV) must adhere to antiretroviral therapy (ART).
Juan Manuel Leyva-Moral, Patrick Albert Palmieri, Blanca Katiuzca Loayza-Enriquez, Kara Lynette Vander Linden, Ursula Elisa Elias-Bravo, Genesis Masiel Guevara-Vasquez, Lucy Yonmey Davila-Olano, Mariela Patricia Aguayo-Gonzalez   +7 more
doaj   +1 more source

Qualitative Environmental Health Research: An Analysis of the Literature, 1991-2008 [PDF]

, 2010
BACKGROUND. Recent articles have advocated for the use of qualitative methods in environmental health research. Qualitative research uses nonnumeric data to understand people's opinions, motives, understanding, and beliefs about events or phenomena ...
Arcury TA, Evans D, Haines MM, Halvorson SJ, Higgins JPT, Larsson LS, Lobdell DT, MacQueen KM, Madeleine Kangsen Scammell, Patton MQ, Peterson CL, Petitti DB, Phaswana-Mafuya N, Snape D, Stemler S, Tu K, Ulin PR, Wing S   +17 more
core   +5 more sources