Results 41 to 50 of about 5,385,043 (357)

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Life with Technology Among University of Pennsylvania Students [PDF]

open access: yes, 2015
Each student in the Qualitative Methods Research Class (SW781), Fall 2015, recruited a study participant (n=26) (undergraduate and graduate students from across the University) and trained them in the appropriate and ethical use of this method.
Frasso, Rosemary   +1 more
core   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

open access: yesMolecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan   +4 more
wiley   +1 more source

‘Staying alive’ with antiretroviral therapy: a grounded theory study of people living with HIV in Peru

open access: yesBMJ Global Health, 2021
Background To achieve an optimal quality of life through chronic disease management, people living with HIV (PLHIV) must adhere to antiretroviral therapy (ART).
Juan Manuel Leyva-Moral   +7 more
doaj   +1 more source

Penn and The Surrounding Community [PDF]

open access: yes, 2016
Photo-elicitation was first named in a paper published by the photographer and researcher John Collier (1957). It involves a qualitative interview stimulated and guided by participant-generated photographs.
Frasso, Rosemary   +1 more
core   +1 more source

Research essentials: An introduction to qualitative research for the novice children’s nurse [PDF]

open access: yes, 2015
QUALITATIVE RESEARCH is ‘a form of social inquiry that focuses on the way people make sense of their experiences and the world in which they live’ (Holloway 2013). Qualitative methods can explore complex issues where little is known, gaining new insights
Chudleigh, Jane, Smith, Joanna
core   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

open access: yesFEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Wearables in sociodrama: An embodied mixed-methods study of expressiveness in social interactions

open access: yesWearable Technologies, 2022
This mixed-methods study investigates the use of wearable technology in embodied psychology research and explores the potential of incorporating bio-signals to focus on the bodily impact of the social experience.
Katerina El-Raheb   +8 more
doaj   +1 more source

Pressure: Students use qualitative methods to explore the meaning of pressure among graduate students here at the University of Pennsylvania [PDF]

open access: yes, 2014
Each student investigator (n=14) in Qualitative Methods Research Class (SW781), 2014, recruited a study participant (graduate students from across the university) and trained them in the appropriate and ethical use of photography in this context.
Frasso, Rosemary   +1 more
core   +1 more source

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