Results 91 to 100 of about 54,781,618 (350)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Ethical Considerations in Qualitative Study

open access: yesINTERNATIONAL JOURNAL OF CARE SCHOLARS, 2018
The protection of human subjects through the application of appropriate ethical principles is important in all research study. In a qualitative study, ethical considerations have a particular resonance due to the in-depth nature of the study process. The
S. R. Mohd Arifin
semanticscholar   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Retention of high-potential employees in a development finance company

open access: yesSA Journal of Human Resource Management, 2017
Orientation: The loss of high-potential employees was a concern to leaders at a South African development finance company. The research question that guided the study was: How can high-potential employees be retained in the company?
Lishani Letchmiah, Adèle Thomas
doaj   +1 more source

A qualitative study of children, young people and 'sexting' : English [PDF]

open access: yes, 2012
The purpose of this small scale qualitative research was to respond to and enhance our understandings of the complex nature of sexting and the role of mobile technologies within peer teen networks.
Gill, Rosalind   +3 more
core   +2 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Transfer of brand knowledge in business-to-business markets: A qualitative study [PDF]

open access: yes, 2009
This is the author's accepted manuscript (under the provisional title "Transfer of brand knowlede in business-to-business markets by brand when personified as a human: A qualitative study").
Michael Bourlakis   +3 more
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Patients’ quality of life during active cancer treatment: a qualitative study

open access: yesBMC Cancer, 2018
Patients’ quality of life has become a major objective of care in oncology. At the same time, it has become the object of increasing interest by researchers, working with both quantitative and qualitative methods.
J. Sibeoni   +6 more
semanticscholar   +1 more source

Public Service motivation for executive pension trustees: A qualitative study [PDF]

open access: yes, 2016
The purpose of this paper is to establish if there is an element of public service motivation (PSM) in pension trustee roles that extend across public and private boundaries in the UK.
Sayce, Susan
core  

Home - About - Disclaimer - Privacy