Results 41 to 50 of about 33,406,320 (250)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Retention of high-potential employees in a development finance company

open access: yesSA Journal of Human Resource Management, 2017
Orientation: The loss of high-potential employees was a concern to leaders at a South African development finance company. The research question that guided the study was: How can high-potential employees be retained in the company?
Lishani Letchmiah, Adèle Thomas
doaj   +1 more source

Nurses' viewpoints on factors affecting ostomy care: A qualitative content analysis

open access: yesNursing Open, 2023
Aims Ostomy plays an important role in management of medical conditions, especially postoperative status of colorectal and bladder cancers. Nurses who have the highest contact level with these patients, face many situations while providing care and need ...
Ladan Naseh   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Nursing Dilemmas in Chemotherapy-Induced Peripheral Neuropathy: A Qualitative Study of a Tertiary Hospital in China

open access: yesJournal of Pain Research, 2023
Jia Xin Fan,1,2,* Ya Chen Hu,1,2,* XinXin Chen,1,2,* YuMei Li2 1School of Medicine, Tongji University, Shanghai, People’s Republic of China; 2Department of Nursing, Shanghai Pulmonary Hospital, Tongji University, Shanghai, People’s Republic ...
Fan JX, Hu YC, Chen X, Li Y
doaj  

Guide for reporting a qualitative study [PDF]

open access: yesمجله ایرانی آموزش در علوم پزشکی, 2022
Letter To ...
Fatemeh Ebrahimpour   +1 more
doaj  

Qualitative Psychology Nexus, Vol. VII: Qualitative Approaches in the Field of Psychology

open access: yes, 2008
Volume 7 of Qualitative Psychology Nexus contains contribution to the meeting 2008 of the Center for Qualitative Psychology in Erkner/Berlin. The general topic was to discuss the importance of qualitative approaches in psychology.
Huber, Günter L.   +13 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

The value of choice: a qualitative study [PDF]

open access: yesBritish Journal of General Practice, 2008
Providing choice in health care is part of an ongoing policy initiative.To explore how people understand choice in healthcare provision.A qualitative study using semi-structured interviews.South East England.Twenty-two people were interviewed about the issue of choice in general, and choice in healthcare in particular. Data were analysed using template
Barnett, J, Ogden, J, Daniells, E
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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