Results 251 to 260 of about 3,493,135 (324)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Commercialization of the Xalkori Pediatric Multiparticulate Product Using Quality-by-Design Principles. [PDF]

Pharmaceutics
Bartlett J, Culver N, Zhang X, Waybrant B, Sullivan H, Howell L.   +5 more
europepmc   +1 more source

Quality by Design (QbD)-Driven Development and Optimization of Tacrolimus-Loaded Microemulsion for the Treatment of Skin Inflammation. [PDF]

Pharmaceutics
Srishti SA, Pinky PP, Taylor R, Guess J, Karlik N, Janjic JM.   +5 more
europepmc   +1 more source

Implementation of Established Conditions and Use of Quality by Design Principles during Drug Development: Status in the US, EU, and Japan. Data from a Survey Conducted by the Japan Pharmaceutical Manufacturers Association (JPMA). [PDF]

Ther Innov Regul Sci
Nakayama Y, Yamauchi S, Shimizume K, Nakanishi A, Masuyama M, Ozaki Y, Nakamura K, Fujikawa M, Kobayashi M, Kashitani Y.   +9 more
europepmc   +1 more source

Quality by design for mRNA platform purification based on continuous oligo-dT chromatography. [PDF]

Mol Ther Nucleic Acids
Qu J, Nair A, Muir GW, Loveday KA, Yang Z, Nourafkan E, Welbourne EN, Maamra M, Dickman MJ, Kis Z.   +9 more
europepmc   +1 more source

Quality-by-design-engineered mitochondrial targeted nanoparticles for glioblastoma therapy. [PDF]

RSC Adv
Dahifale A, Agnihotri TG, Jain A, Jain A.   +3 more
europepmc   +1 more source

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Quality by Design

Methodologies in Biosimilar Product Development, 2021
: - The contemporary method for pharmaceutical product quality is called "Quality by Design." This essay provides information on Pharmaceutical Quality by Design (QBD) and discusses how it is used to guarantee the high calibre of pharmaceuticals. Some of
Min Joo Choo, Ji Youn Kim, Shein-Chung Chow, Sang Joon Lee   +3 more
openaire   +2 more sources

Quality by design

A European Television Fiction Renaissance, 2020
A. Majer
openaire   +2 more sources