Results 91 to 100 of about 1,021,436 (277)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Forced Freebies: A Note on Partial Deregulation with Pro Bono Supply Requirements [PDF]

The liberalization of many former state governed natural monopolies in sectors such as electricity, railroad and telecommunications is done by partial deregulation. Typically, entry is invited into elements of the production chain, yet under strict price
Schinkel, M.P., Tuinstra, J.
core  

You Manage What You Measure: Using Mobile Phones to Strengthen Outcome Monitoring in Rural Sanitation [PDF]

, 2012
This paper addresses the sanitation challenge in India, where it is home to the majority of people defecating in the open in the world and also one of the top rapidly growing emerging economies.
C. Kumar, Upneet Singh
core  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

FRUITFULL2 controls tomato fertility through style length and pollen quality

Horticultural Plant Journal
Tomato reproductive success and yield are particularly vulnerable to the negative effect of heat stress leading to stigma exsertion (protrusion) and lower pollen viability, both interfering with fertilization.
Xiaowei Wang, Monica Lanzoni Rossi, Adriana Pinheiro Martinelli, Gerco C. Angenent, Ruud A. de Maagd   +4 more
doaj   +1 more source

Security Controls for Employees’ Satisfaction: Perspective of Controls Framework

SAGE Open, 2019
As previous literature on the effect of controls usage on the outcome of controls (controls effectiveness) are rare, this study intends to use controls framework to explain controls effectiveness as HIS (hotel information system) quality and user ...
Sangjae Lee, Seongil Jeon, ByungWon Lee
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Comparison of sleep quality, diet quality, and weight change between COVID‐19‐recovered patients and healthy controls: A matched case‐control study

Health Science Reports
Background and Aim Literature suggests that individuals who have recovered from COVID‐19 may experience post‐COVID conditions, including sleep problems and alterations in smell or taste.
Farha Ainin Sofia Muzaffar, Seok Tyug Tan   +1 more
doaj   +1 more source