Results 141 to 150 of about 185,840 (263)

Clinical Pharmacology Quality Assurance Program for Global HIV and Co-Infection Drug Development. [PDF]

Clin Pharmacol Ther
DiFrancesco R, Wood TD, Cha R, Hochreiter JS, Rosenkranz SL, Farhad M, Whitson KR, Gould CE, Hill LE, Hale LL, Lindhorst PH, Ghazal D, Taylor CR, Quraishi M, Siminski SM, Cramer Y, Sprenger HL, Morse GD.   +17 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

COMP Report: Patient-specific quality assurance practices in Canadian radiotherapy-results from a national survey. [PDF]

J Appl Clin Med Phys
Tran MN, Larouche RX, Dobberthien B, Varfalvy N, Kamta GL, Wright P, Lee R, Chan GH.   +7 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Identification of diagnostic discrepancies as a quality assurance measure in emergency medicine - a validation study. [PDF]

Scand J Trauma Resusc Emerg Med
Marcin T, Werthmüller N, Kölbener F, Müller M, Zwaan L, Hautz SC, Schuster A, Exadaktylos AK, Hautz WE.   +8 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Quality assurance of functional food products using physical field-assisted freezing. [PDF]

Front Nutr
Tyutkov N, Lemeshonok E, Sorokina A, Aleksandrova I, Ilina V, Lepeshkin A, Baranenko D.   +6 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Development of a virtual phantom for HDR cervical cancer brachytherapy: A multi-institutional tool for training, quality assurance, and variability reduction. [PDF]

J Appl Clin Med Phys
Iijima K, Okamoto H, Ushijima T, Ueda Y, Oku Y, Toyota M, Ono Y, Takatsu J, Fukunaga JI, Murakami N, Ohno T.   +10 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source