Results 61 to 70 of about 1,067,596 (303)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Greenness analysis of stability indicating RP-HPLC method for determination of lobeglitazone sulphate and glimepiride in tablets

Discover Chemistry
The present study focuses on the development and validation of a stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous quantification of lobeglitazone sulfate (LBG) and glimepiride (GLM) in ...
Aashiya Patel, Aesha Bhalodia, Sonal Desai, Suchi Desai, Yachita Jokhi, Megha Shah   +5 more
doaj   +1 more source

Developing a quality assurance model for small military institutions [PDF]

, 2008
Bahrain Defence Force (BDF) has a limited manpower, land to manoeuvre and resources. This reason has led the researcher to investigate the effective dimensions of discovering a model for quality assurance in higher education within a military context in ...
Bahzad, Y, Irani, Z
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

An Overview on Toxicity Reduction and Environmental Remediation

Proceedings
Toxicity reduction and environmental remediation are crucial aspects of addressing pollution and protecting ecosystems and human health [...]
Harsha Vasudev Chaudhari, Javesh Kashinath Patil, Devshree Yashwantbhai Patel, Aniket Rajesing Girase, Hasni Hamid Yahiya Sayyed   +4 more
doaj   +1 more source

ATLAS RPC Quality Assurance results at INFN Lecce [PDF]

, 2006
The main results of the quality assurance tests performed on the Resistive Plate Chamber used by the ATLAS experiment at LHC as muon trigger chambers are reported and discussed.
Bianco, M., Borjanovic, I., Cataldi, G., Cazzato, A., Chiodini, G., Coluccia, M. R., Creti, P., Gorini, E., Grancagnolo, F., Perrino, R., Primavera, M., Spagnolo, S., Tassielli, G., Ventura, A.   +13 more
core   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Quality Improvement Method for EMU Bogie Components Based on Statistical Process Control of Nondestructive Testing Data

Chengshi guidao jiaotong yanjiu
ObjectiveDue to inconsistent formats, nonstandard statistical practices, and disconnection from manufacturing processes, the nondestructive testing (NDT) data for EMU (electric multiple unit) bogies are insufficient to support the quality improvement of ...
Haoqi BI, Quanchao SONG, Yang LI, Zinan WANG, Guanghao ZHOU   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source