Results 151 to 160 of about 8,352,919 (357)

Spatial Transcriptomics and snRNA‐seq Expose CAF Niches Orchestrating Dual Stromal‐Immune Barriers in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
HmmyCAFs may form a triple immunosuppressive niche: possibly secrete ECM (POSTN, etc.) as physical barriers to block CD8⁺ T cells, induce CD8⁺ T exhaustion via those molecules, and use HIF‐1α‐driven metabolism to create acidic, nutrient‐poor microenvironments that suppress T cells.
Yingxue Li   +12 more
wiley   +1 more source

IMPORTANCE OF FINANCIAL AUDIT IN LOWERING INFORMATIONAL RISK [PDF]

open access: yes
The financial audit enables the credibility of the financial statements to be improved, from both accountants and financial information users’ standpoints. This audit is required to provide information quality control.
Gabriela JINGA
core  

Dual‐Pedicle Tissue‐Engineered Trachea Promotes Biomimetic Cartilaginous Framework, Vascularization, and Epithelial Lining for Long‐Segment Tracheal Reconstruction

open access: yesAdvanced Science, EarlyView.
Overcoming the limitations of conventional grafts, a biomimetic trachea with two independent vascular pedicles enables rapid integration and sustained patency. This approach markedly improves survival rates, restores the epithelial barrier, and promotes regenerative pathways, presenting a transformative paradigm for clinical application.
Ziming Wang   +9 more
wiley   +1 more source

National Beef Quality Audit-2016: In-plant survey of carcass characteristics related to quality, quantity, and value of fed steers and heifers.

open access: yesJournal of Animal Science, 2017
C. A. Boykin   +25 more
semanticscholar   +1 more source

Single‐Cell Nucleus Extraction with Cellular Indexing

open access: yesAdvanced Science, EarlyView.
VacTrap is a multilayer, high‐throughput microfluidic system that isolates and spatially indexes single nuclei from hundreds of cells within minutes. Using dissolvable hydrogel trapdoors triggered by chemical and vacuum actuation, VacTrap synchronously transfers nuclei while preserving spatial links to parent cells.
Trinh Lam   +7 more
wiley   +1 more source

Auditor independence, audit committee quality and internal control weaknesses [PDF]

open access: yes
In this paper we investigate the relation between auditor independence, audit committee quality and the disclosure of internal control weaknesses.
Sorin-Sandu Vinatoru, Sorinel Domnisoru
core  

Machine Learning for Green Solvents: Assessment, Selection and Substitution

open access: yesAdvanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta   +4 more
wiley   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

open access: yesAdvanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

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