Results 131 to 140 of about 4,188,222 (350)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Cost modelling and concurrent engineering for testable design

, 1993
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.As integrated circuits and printed circuit boards increase in complexity, testing becomes a major cost factor of the design and production of the complex ...
Dick, J.H, Dick, Jochen Helmut
core  

Training for design of experiments using a catapult

, 2002
Design of experiments (DOE) is a powerful approach for discovering a set of process (or design) variables which are most important to the process and then determine at what levels these variables must be kept to optimize the response (or quality ...
Antony, Jiju, Jiju Antony
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Formulation and Evaluation of Budesonide-loaded Nanosponges for Colon-specific Drug Delivery Systems

BIO Integration
Background: The purpose of this work was to complex budesonide with cyclodextrin-based nanosponges to improve its solubility and stability. The current study focused on polysaccharide systems that have undergone minimal chemical alteration and have been ...
Chetana Kapadne, Sourabh Birari, Vishal Gulecha, Anita Shinde, Aishwarya Sambare, Sanjay Kshirsagar   +5 more
doaj   +1 more source

Sensitivity analysis modelling for microscale multiphysics robust engineering design

, 2007
Sensitivity Analysis (SA) plays an important role in the development of any practical engineering model. It can help to reveal the sources and mechanisms of variability that provide the key to understanding system uncertainty.
Bates, RA, Wynn, H, Perry, M, Atherton, MA, Oldfield, M   +4 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Developing a QFD-Based design-integrated structural analysis methodology

, 2012
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Design of the mechanical components greatly depends on their expected structural performances.
Mobasseri, Seyed Omid
core  

Improving Patient Flow Through Axiomatic Design of Hospital Emergency Departments [PDF]

, 2009
Organised by: Cranfield UniversityIn response to crowding in hospital emergency departments (ED), efforts have been made to increase patient flow through the Fast Track (FT).
Kim, S-G., Peck, J.
core