Results 31 to 40 of about 3,032,107 (315)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Clinical approbation today: analysis of current problems and solutions

open access: yesФармакоэкономика, 2023
Objective: description of the current problems concerning the development and conducting of a protocol of clinical approbation (CA) of methods of prevention, diagnosis, treatment and rehabilitation to optimize the implementation of innovative medical ...
V. V. Omelyanovskiy   +6 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Criteria and practical guidance for determination of brain death in adults (BQCC version)

open access: yesChinese Journal of Contemporary Neurology and Neurosurgery, 2015
DOI: 10.3969/j.issn.1672-6731.2015.12 ...
Brain Injury Evaluation Quality Control National Health and Family Planning Commission
doaj  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Optimization of Disinfection of Raw Wheat Sprout by Combination of Ultrasonic and Citric Acid Using Response Surface Methodology (RSM)

open access: yesJournal of Food Quality
This study investigated the synergistic effects of ultrasound (US) and citric acid (CA) on the microbial load and chemical quality of raw wheat sprouts, leveraging a nonthermal approach for food safety enhancement.
Maryam Safarirad   +4 more
doaj   +1 more source

EVALUATING THE USE OF HOSPITAL BED CAPACITY IN MEDICAL ORGANIZATIONS

open access: yesФармакоэкономика, 2018
Since recently, a number of normative legal acts aimed at increasing the salaries of medical professionals in the Russian Federation have been implemented.
I. A. Zheleznyakova   +4 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

A systematic review of the clinical effectiveness of monitoring patients with diabetes mellitus using individual blood glucose meters with function of transmitting measurements via gsm channel or via the internet

open access: yesСахарный диабет, 2019
BACKGROUND: In recent years, there has been an active introduction of telecommunication technologies in various spheres of scientific and practical knowledge, including medicine.
Vlada K. Fedyaeva   +2 more
doaj   +1 more source

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