Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
ESTIMATION OF INDICATORS OF QUALITY OF LIFE AND LEVEL OF CONTROL IN ASTHMA PATIENTS OF YOUNG AGE
, 2017 Е. А. Собко +15 more
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Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Public Policy and Diet Quality: Impact of Prices on Nutrient Adequacy using French Expenditure Data from 1996 to 2005 [PDF]
This paper aims at simulating optimal prices satisfying public health recommendations in terms of nutrient adequacy. This implies to estimate a complete food demand system in order to compute price elasticities.
Allais, Olivier +3 more
core +1 more source
Real-time Regulation of Detention Ponds via Feedback Control: Balancing Flood Mitigation and Water Quality [PDF]
arXivDetention ponds can mitigate flooding and improve water quality by allowing the settlement of pollutants. Typically, they are operated with fully open orifices and weirs (i.e., passive control). Active controls can improve the performance of these systems: orifices can be retrofitted with controlled valves and spillways can have controllable gates. The
arxiv
Quality Markers of Traditional Chinese Medicine: Concept, Progress, and Perspective
Engineering, 2019 As the most important complementary medication against a variety of diseases, traditional Chinese medicines (TCMs) have been extensively applied over thousands of years. Current quality control of herbal medicines, however, is in great dispute.
Yazhuo Li +5 more
doaj
Arginine, as a Key Indicator for Real-Time Stability Monitoring of Quality Control in the Newborn Screening Test Using Dried Blood Spot [PDF]
, 2021 Hyunseung Lee
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Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
STATE CONTROL OVER THE SAFETY AND INDIVIDUAL QUALITY INDICATORS OF LIVESTOCK PRODUCTS IN UKRAINE
, 2019 Iryna Kyryliuk, Yevhenii Kyryliuk
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Molecular Oncology, EarlyView.CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan +6 more
wiley +1 more source