Results 231 to 240 of about 3,714,471 (406)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Sleep regularity index as a novel indicator of sleep disturbance in stroke survivors: a secondary data analysis. [PDF]

Sci Rep
Schruers KB, Weightman M, Guttesen AÁV, Robinson B, Johansen-Berg H, Fleming MK.   +5 more
europepmc   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Developing a quality indicator system for pediatric clinical trials management of research centers in China: a modified Delphi-Analytic Hierarchy Process study. [PDF]

BMC Pediatr
Liu C, Liu Y, Xuan B, Qi Y, Ou L, Zhang J.   +5 more
europepmc   +1 more source

263. An Evaluation of Quality Indicators for the Management of Staphylococcus aureus Bacteremia: A Nested Case-Control Study [PDF]

, 2020
Andrew Simms, Marin L. Schweizer, Michael Ohl, Eli N. Perencevich, Michihiko Goto   +4 more
openalex   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Biosafety status analysis and risk assessment of laboratories from 2021 to 2023 in Jiaxing, China. [PDF]

Front Bioeng Biotechnol
Yan Y, Li C, Xu J, Gao L, Jiang Z, Lv S, Li P, Xiang Z, He P, Ren G, Zhu G, Chen Z.   +11 more
europepmc   +1 more source

The Effect of Ageing (Using Controlled Deterioration) on the Germination at 21°C as an Indicator of Physiological Quality of Seed Lots of Fourteen Bangladeshi Rice (Oryza sativa L.) Cultivars [PDF]

, 2003
M.G. Ali, Robert E. L. Naylor, S. Matthews   +2 more
openalex   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Evaluation of Nosocomial Infection Management Efficiency Based on the Data Envelopment Analysis Model. [PDF]

Risk Manag Healthc Policy
Wang J, Wang G, Qi C.
europepmc   +1 more source