Results 81 to 90 of about 1,742,858 (300)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Evaluation of the Quality Indicators in Laboratories at National AIDS Research Institute, Pune, India

National Journal of Community Medicine, 2017
Introduction: Quality indicators in a clinical laboratory are considered as useful tools for continual improvement of the laboratory services. Aim: The aim of this study was to assess timely performance of the NARI service laboratories in three ...
Sangeeta Kulkarni, Sachin Kale, Urmila Ghodke, Arun Risbud, Smita Kulkarni   +4 more
doaj  

Usefulness of quality indicators in the management of clinical laboratories [PDF]

, 2011
O uso dos indicadores da qualidade vem sendo valorizado na gestão dos laboratórios clínicos para otimizar a qualificação e a quantificação das falhas nos diferentes processos laboratoriais, bem como para auxiliar a implantação de medidas corretivas e ...
MENDES, Maria Elizabete, SHITARA, Edson Shusaku, SUMITA, Nairo Massakazu, VIEIRA, Keila Furtado   +3 more
core   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Is the readmission rate a valid quality indicator? A review of the evidence.

PLoS ONE, 2014
IntroductionHospital readmission rates are increasingly used for both quality improvement and cost control. However, the validity of readmission rates as a measure of quality of hospital care is not evident.
Claudia Fischer, Hester F Lingsma, Perla J Marang-van de Mheen, Dionne S Kringos, Niek S Klazinga, Ewout W Steyerberg   +5 more
doaj   +1 more source

Link Quality Estimation Method for Wireless Sensor Networks Based on Stacked Autoencoder

IEEE Access, 2019
In wireless sensor networks, effective link quality estimation is the basis of topology management and routing control. Effective link quality estimation can guarantee the transmission of data, as well as improve the throughput rate, and hence, extend ...
Xionghui Luo, Linlan Liu, Jian Shu, Manar Al-Kali   +3 more
doaj   +1 more source

Measuring Food Safety Control in U.S. Hog Farms Using a Composite Indicator [PDF]

Consumer demand for reliable food product quality and safety is growing. This trend, together with increased public regulation and attention to the legal liability of food processors and retailers creates derived demand for food safety assurance in farm ...
Dong, Fengxia, Jensen, Helen H.
core   +1 more source

Models and measures to evaluate the effectiveness of funds utilization for scientific research and development of advanced technologies [PDF]

, 2011
The purpose of this report was to construct some alternative methods to estimate the effectiveness of investments in scientific research and development of advanced technologies, especially their long-term effects.
Agnieszka, Kaszkowiak, Anna, Kortyka, Jacek, Lewkowicz, Jakub, Lengiewicz, John, Ockendon, Karolina, Wojtasik, Krzysztof, Turek, Maciej, Zmuda, Mariusz, Marczewski, Piotr, Wojdyllo, Poul, Hjorth, Wojciech, Okrasinski, Zbigniew, Peradzynski   +12 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source