Results 131 to 140 of about 2,862,737 (350)

Recommendations for the application and follow-up of quality controls in medical laboratories. [PDF]

open access: yesBiochem Med (Zagreb), 2021
Giannoli JM   +15 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Crossroads for Federal Enforcement of the Clean Air Act [PDF]

open access: yes, 1996
A major goal of the Clean Air Act 1 (hereinafter CAA or Act ) is to protect and enhance the quality of the Nation\u27s air resources. 2 The Act uses a two tiered approach to accomplish this goal.
Martin, Joyce M.
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Sulfur isotope analysis of collagen: Quality controls and proboscidean wetland habitats

open access: yesQuaternary Environments and Humans
Sulfur isotopes (δ34S values) have significant potential for addressing archaeological, paleontological, and paleoecological research questions.
Jessica Z. Metcalfe   +3 more
doaj   +1 more source

Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls. [PDF]

open access: yesStem Cell Reports, 2022
Simkin D   +12 more
europepmc   +1 more source

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