Results 211 to 220 of about 2,862,737 (350)
Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa +15 morewiley +1 more sourceOzone-related acute excess mortality projected to increase in the absence of climate and air quality controls consistent with the Paris Agreement. [PDF]
One EarthDomingo NGG, Fiore AM, Lamarque JF, Kinney PL, Jiang L, Gasparrini A, Breitner S, Lavigne E, Madureira J, Masselot P, das Neves Pereira da Silva S, Sheng Ng CF, Kyselý J, Guo Y, Tong S, Kan H, Urban A, Orru H, Maasikmets M, Pascal M, Katsouyanni K, Samoli E, Scortichini M, Stafoggia M, Hashizume M, Alahmad B, Diaz MH, la Cruz Valencia C, Scovronick N, Garland RM, Kim H, Lee W, Tobias A, Íñiguez C, Forsberg B, Åström C, Ragettli MS, Guo YL, Pan SC, Colistro V, Bell M, Zanobetti A, Schwartz J, Schneider A, Vicedo-Cabrera AM, Chen K. +45 moreeuropepmc +1 more sourceQuality controlled turbulent fluxes of co-emitted species (CO, NOx, CH4, N2O) from each city (CHHar, FR-Rmv, DE-Opd)
Rainer Hilland, Ann-Kristin Kunz, Jesse Soininen, Andreas Christen, Samuel Hammer, Lars Borchardt, Markus Eritt, Josh Hashemi, Richard Kneißl, Virgile Legendre +9 moreopenalex +1 more sourcePeroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski +17 morewiley +1 more sourceCrucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel +10 morewiley +1 more sourceQuality of life without toxicity or symptoms analysis of a randomized controlled clinical trial comparing efficacy of cabazitaxel versus docetaxel in recurrent head and neck cancer
, 2018 Kumar Prabhash, Vijay Patil, Amit Joshi, Vanita Noronha, Sachin Dhumal, Arun Chandrasekharan, Nikhil Pande, Sameer Shrirangwar, Anup Toshniwal, Siddharth Turkar, Kushal Gupta, Vikas Talreja, Abhishek Mahajan, Shashikant Juvekar, Atanu Bhattacharjee +14 moreopenalex +1 more source
