Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
INTELLECTUAL CAPITAL REPORTING AND DISCLOSURE IN THE ANNUAL REPORTS OF ROMANIAN MANUFACTURING LISTED COMPANIES â€" THEORETICAL FRAMEWORK [PDF]
One of the most researched topic regarding financial reporting and disclosure of today is the way intellectual capital or knowledge assets contributes to the improving of the quality of information disclosed and create or add value to business ...
Bogdan Victoria +2 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
FAKTOR DETERMINAN TINGKAT PENGUNGKAPAN SUKARELA BERBASIS GRAFIK DALAM LAPORAN TAHUNAN PERUSAHAAN PUBLIK DI INDONESIA [PDF]
, 2015 This study aims to examine the effect of firm size, profitability, audit quality, and public ownership on graphical voluntary disclosure. Graphical voluntary disclosure is used as a dependent variable, which is measured by the level of graph disclosure ...
HAPSARI, Cinitya Anum, HARTO, Puji
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Information Disclosure, Intertemporal Risk Sharing, and Asset Prices [PDF]
Disclosure of information triggers immediate price movements, but it mitigates price movements at a later date, when the information would otherwise have become public.
Hendrik Hakenes, Tri Vi Dang
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FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
An Investigation of Voluntary Discovery and Disclosure of Environmental Violations Using Laboratory Experiments [PDF]
This paper uses laboratory experiments to test individual responses to policies that seek to encourage firms to voluntarily discover and disclose violations of environmental standards. We find that while it is possible to motivate a significant number of
James J. Murphy, John K. Stranlund
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Pengaruh Asimetri Informasi, Pengungkapan Modal Intelektual, dan Kualitas Audit terhadap Biaya Modal Ekuitas (Studi pada Perusahaan Lq 45 yang Terdaftar di Bursa Efek Indonesia Tahun 2012-2014) [PDF]
, 2016 The research examines the effect of asymmetry information, intellectual capital disclosure, and audit quality on cost of equity capital. This research was an empirical study using multiple regression analysis.
Ariani, N. E. (Nita) +1 more
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