Results 91 to 100 of about 8,449,104 (300)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
2015 student experience survey national report
, 2016 Provides a national architecture for collecting feedback on key facets of the higher education student experience Executive summary The Student Experience Survey (SES) was originally developed as the University Experience Survey (UES) in 2011, to ...
Quality Indicators for Learning and Teaching
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2014 Texas Integrated Report Index of Water Quality Impairments [PDF]
, 2015 This technical report briefly describes the location and type of water quality concerns in Waller Creek.Waller Creek Working ...
Texas Commission on Environmental Quality
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Clinical Epidemiology, 2020 Pia Kjær Kristensen,1,2 Niels Dieter Röck,3 Helle Collatz Christensen,4 Alma Becic Pedersen1 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of Orthopaedic Surgery, Horsens Regional Hospital ...
Kristensen PK +3 more
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Приборы и методы измерений, 2017 Objects quality is usually assessed by a complex indicator. It includes single quality indicators with their significance factors. The convolution of the corresponding dependencies represents average weighted quantities: arithmetic, geometric, harmonic ...
A. M. Dolzhanskiy +2 more
doaj +1 more source
A statistical framework for model based air quality indicators and population risk evaluation
, 2012 This paper is devoted to the development of a statistical framework for air quality assessment at country level and for the evaluation of the ambient population exposure and risk with respect to airborne pollutants.
Scott, Marian E. +2 more
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