Results 21 to 30 of about 18,534 (261)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analysis of the Effect of Economic Development on Air Quality in Jiangsu Province Using Satellite Remote Sensing and Statistical Modeling

Atmosphere, 2022
In recent decades, the economy of China has developed rapidly, but this has brought widespread damage to the environment, which forces us to explore a sustainable, green, economic development model.
Jia Jia, Yan You, Shanlin Yang, Qingmei Shang   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Methodology for the control of electric power distribution system components to ensure the quality of consumed electricity

Научно-технический вестник информационных технологий, механики и оптики
Electric power system is a complex organizational structure that provides working interaction for its constituent intelligent electronic devices by defining their roles, communication channels, and powers.
A. E. Mozokhin, V. N. Shvedenko
doaj   +1 more source

ALTERNATIVE INDICATORS OF POWER OF ELECTRIC ENERGY IN A SINGLE-PHASE CIRCUIT WITH POLYHARMONIC CURRENT AND VOLTAGE

Electrical engineering & Electromechanics, 2019
Introduction. Many electrical engineering issues use a power balance. It is compiled from averaged power values, and equivalent power is used to characterize power of transient processes.
O. V. Bialobrzeski, D. I. Rodkin
doaj   +1 more source

Modeling of Voltage Fluctuations Generated by Arc Furnaces

Applied Sciences, 2021
Arc furnaces can be classified as electricity receivers, which largely affect the quality of electricity in the power system. Voltage fluctuations are the main disturbance generated by arc furnaces.
Zbigniew Olczykowski
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

АНАЛІЗ ПОКАЗНИКІВ ЯКОСТІ ПОСЛУГ ПОСТАЧАННЯ ЕЛЕКТРИЧНОЇ ЕНЕРГІЇ

Праці Інституту електродинаміки Національної академії наук України
The object of the study is the processes in distribution electric networks and their influence on technical and economic characteristics aimed at achieving the main indicators of reliability, which is characterized by the continuity of electricity supply,
В.В. Черкашина, О.В. Яковенко   +1 more
doaj   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source