Results 91 to 100 of about 5,207,310 (345)

Quality Management System-INcrease Factor of the Organizational Competitiveness [PDF]

Modern organizations operate in an extremely turbulent, dynamic and unpredictable environment, which bear profound changes in relatively short periods of time and impose requirements in terms of increased economic competition and the intended performance
Constantin BAGU, Svetlana BRADUTAN
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Institutions and Water -- the Vital Connections [PDF]

This Policy Notes looks into the current two-tiered system of water governance in the Philippines. It argues that despite the presence of certain national-local interfaces among the institutions involved in water governance, the multiplicity of ...
Elazegui, Dulce D.
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Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Integration management system – new of requirements of ISO 9001:2015 and ISO 14001:2015 standards

Production Engineering Archives, 2016
Organizations are becoming more aware of the importance of integrated management systems (IMS). Interest in this subject indicates that IMS are seen as "management systems of the future“.
Renata Nováková, Katarína Čekanová, Alena Pauliková   +2 more
doaj  

Epitranscriptomic modifications for enhancing abiotic stress resistance in plants

Frontiers in Plant Science
Climate change significantly impedes agricultural growth, development, and production. Plants adapt to environmental changes via the plasticity given by essential genes, which are regulated at the post-/transcriptional level. Gene regulation in plants is
Yunmin Zeng, Yunmin Zeng, Abid Muhammad, Lingyun Wan, Chenlu Gao, Pinyao Zhao, Ahmed H. El-Sappah, Ahmed H. El-Sappah   +7 more
doaj   +1 more source

QUALITY MANAGEMENT PRINCIPLES – AN APPROACH IN HEALTHCARE INSTITUTIONS [PDF]

The problems of quality management systems development don´t seem to be interesting for healthcare institutions (HCI) at a glance. But a lot of managers and employees of HCI (including physicians) have already understood that their organizations also ...
Kristina Zgodavova, Sofia Elena Colesca
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An iterative approach for lexicon characterization in juridical context [PDF]

, 2010
In the juridical context, knowledge management applications have a central role. In order to improve the effectiveness of document management procedures, techniques for automatic comprehension of textual content are required.
AMATO, FLORA, MAZZEO, ANTONINO, ROMANO, SARA, SCIPPACERCOLA, SERGIO   +3 more
core  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source