Results 91 to 100 of about 1,316,082 (254)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Considerations Regarding the Quality Management of Banking Services [PDF]

Ovidius University Annals: Economic Sciences Series, 2016
Efforts that Romanian banking institutions must make to increasing the competitiveness ofservices are becoming increasingly difficult to sustain and lead to a price - quality ratio to beproperly appreciated.
Anca Cristina Stanciu, Mihaela Constandache, Daniela Simona Nenciu   +2 more
doaj  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A quality management system aiming to ensure regulatory-grade data quality in a glaucoma registry. [PDF]

PLoS One, 2023
Wada S, Tsuda S, Abe M, Nakazawa T, Urushihara H.   +4 more
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Practical considerations for laboratories: Implementing a holistic quality management system. [PDF]

Front Bioeng Biotechnol, 2022
Pillai S, Calvert J, Fox E.
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Correction: Quality Tolerance Limits' Place in the Quality Management System and Link to the Statistical Trial Design: Case Studies and Recommendations from Early Adopters. [PDF]

Ther Innov Regul Sci, 2023
Wolfs M, Bojarski Ł, Young S, Cesario L, Makowski M, Sullivan LB.   +5 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Implementation of laboratory quality management system: A cornerstone for enhanced patient safety and clinical outcomes in Tanzania

Journal of Interventional Epidemiology and Public Health
Laboratory Quality Management Systems (LQMS) is a structured framework that integrates policies, processes, and procedures to manage and improve the quality and reliability of laboratory services.
Vulstan James Shedura, Kenan Kenan Malindisa, Shaibu Jabiri Nanyanga   +2 more
doaj   +1 more source