Results 41 to 50 of about 5,317,459 (348)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

KNOWLEDGE MANAGEMENT TECHNOLOGIES IN VIEW OF IMPLEMENTATION OF QUALITY MANAGEMENT

open access: yesВісник Київського національного університету імені Тараса Шевченка. Серія Економіка, 2015
The paper reveals actual problems of development and implementation of international quality standards. Authors proposed KM-oriented model of organizational learning both in view of implementation of total quality management concept and realization of ...
L. Anisimova, V. Pryimak
doaj   +1 more source

Integrating automated support for a software management cycle into the TAME system [PDF]

open access: yes, 1989
Software managers are interested in the quantitative management of software quality, cost and progress. An integrated software management methodology, which can be applied throughout the software life cycle for any number purposes, is required. The TAME (
Basili, Victor R., Sunazuka, Toshihiko
core   +1 more source

Understanding transitions of care in older adults with hip fractures: A qualitative multiple-case study in Ontario

open access: yesInternational Journal of Integrated Care, 2019
Introduction: Transitions in care between and within healthcare sectors are a major focus across health jurisdictions. It is a time of vulnerability for both patients and their families.
Sara J.T. Guilcher   +6 more
doaj   +1 more source

Regional co-variability of spatial and temporal soil moisture–precipitation coupling in North Africa: an observational perspective [PDF]

open access: yesHydrology and Earth System Sciences, 2018
The magnitude and sign of soil moisture–precipitation coupling (SMPC) is investigated using a probability-based approach and 10 years of daily microwave satellite data across North Africa at a 1° horizontal scale. Specifically, the co-existence and co-
I. Y. Petrova   +4 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson   +3 more
wiley   +1 more source

Early warning signals of tipping points in periodically forced systems [PDF]

open access: yesEarth System Dynamics, 2016
The prospect of finding generic early warning signals of an approaching tipping point in a complex system has generated much interest recently. Existing methods are predicated on a separation of timescales between the system studied and its forcing ...
M. S. Williamson   +2 more
doaj   +1 more source

Data Accuracy and Completeness of Monthly Midwifery Returns Indicators of Ejisu Juaben Health Directorate of Ghana [PDF]

open access: yes, 2019
The broad range of activities contained in the provision of Primary Health Care (PHC) places a burden on providers to make optimal use of limited resources to achieve maximal health benefit to the population served.
Agyei-Baffour, P. (Peter)   +2 more
core   +3 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

Higher education quality management system: a methodological aspect

open access: yesОсвітологія, 2018
The article highlights the methodological basis of the higher education quality management system. The problems of quality management in modern scientific research have been revealed.
Batechko Nina, Lut Mykola
doaj   +1 more source

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