Results 121 to 130 of about 6,605,083 (409)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Analysing projects of professionalizing education: The challenge of quality [PDF]
, 2003 This work intends to describe the theoretical-conceptual design of an investigation whose main aim is to analyse and interpret an ongoing process of reconstruction of a teacher education curricular project (1st to the 4th grade teaching) as well as its
César, Margarida +2 more
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Journal of Pharmaceutical Analysis, 2017 A high-performance liquid chromatography coupled with mass spectrometry (HPLC–MS) method was established for the separation and determination of acetyl-glutamine enantiomers (acetyl-L-glutamine and acetyl-D-glutamine) simultaneously.
Xiaoxiao Zhang +3 more
doaj +1 more source
Privacy-preserved data hiding using compressive sensing and fuzzy C-means clustering
International Journal of Distributed Sensor Networks, 2020 Nowadays, digital images are confronted with notable privacy and security issues, and many research works have been accomplished to countermeasure these risks.
Ming Li, Lanlan Wang, Haiju Fan
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Convexity, quality and efficiency in education [PDF]
Journal of the Operational Research Society, 2017 While Data Envelopment Analysis has many attractions as a technique for analysing the efficiency of educational organisations, such as schools and universities, care must be taken in its use whenever its assumption of convexity of the prevailing technology and associated production possibility set may not hold.
openaire +3 more sources
Public Affairs: The Community's Role in Public Education [PDF]
, 2006 Public education is essential for a vibrant democracy, a healthy economy, and a pluralistic society. In the United States, public education is the primary institution that prepares each successive generation to participate in American democracy.
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source