Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
BMC PediatricsBackground Adolescent obesity and associated insulin resistance (IR) are major public health issues. The triglyceride-glucose (TyG) index is a simple IR surrogate, but exercise’s quantitative effect on it and optimal dose–response remain unclear.
Meichun Yang +7 more
doaj +1 more source
An Approach to Leadership Development and Patient Safety and Quality Improvement Education in the Context of Professional Identity Formation in Pre-Clinical Medical Students. [PDF]
J Med Educ Curric Dev, 2023 Inayat H +7 more
europepmc +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
High Workload, and Low Quality Health Education: Vicious Circle in Iran's Rural Primary Health Care (IRPHC). [PDF]
Iran J Public Health, 2022 Heshmati H +4 more
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Quality Improvement Education in the Era of COVID-19: A Pivot Toward Virtual Education. [PDF]
Pediatr Qual Saf, 2021 Cronin JA +5 more
europepmc +1 more source
Earnings functions, labour market discrimination and quality of education in South Africa [PDF]
Education is a key determinant of earnings, as several South African studies have confirmed. Years of schooling completed, however, provides an imperfect approximation of the effective level of education achieved, mainly due to variations in the quality ...
Doubell Chamberlain +1 more
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The effects of homogeneous small groups on the efficacy of problem-based learning
Journal of Advances in Medical Education and Professionalism, 2013 Introduction: Problem-based learning (PBL) as a learning style has gained a special position amongst different levels of education systems, and many different approaches, such as tutor education, proper scenario presentation, etc., are used to ...
JAVAD KOJURI +5 more
doaj