Results 81 to 90 of about 5,811,138 (314)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Privacy-preserved data hiding using compressive sensing and fuzzy C-means clustering

International Journal of Distributed Sensor Networks, 2020
Nowadays, digital images are confronted with notable privacy and security issues, and many research works have been accomplished to countermeasure these risks.
Ming Li, Lanlan Wang, Haiju Fan
doaj   +1 more source

Quality of Life - Education

, 2010
Education is important for social mobility, participation and employment opportunity. High educational attainment level directly impacts quality of life, since it is closely linked to the ability to take advantage of employment opportunities and for social mobility.
openaire   +1 more source

Analysing projects of professionalizing education: The challenge of quality [PDF]

, 2003
This work intends to describe the theoretical-conceptual design of an investigation whose main aim is to analyse and interpret an ongoing process of reconstruction of a teacher education curricular project (1st to the 4th grade teaching) as well as its
César, Margarida, Hamido, Gracinda, Roldão, Maria do Céu   +2 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Separation and determination of acetyl-glutamine enantiomers by HPLC–MS and its application in pharmacokinetic study

Journal of Pharmaceutical Analysis, 2017
A high-performance liquid chromatography coupled with mass spectrometry (HPLC–MS) method was established for the separation and determination of acetyl-glutamine enantiomers (acetyl-L-glutamine and acetyl-D-glutamine) simultaneously.
Xiaoxiao Zhang, Lei Gao, Zunjian Zhang, Yuan Tian   +3 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Relation between Maternal Work Hours and Primary School Students’ Affect in China: The Role of the Frequency of Mother–Child Communication (FMCC) and Maternal Education

Frontiers in Psychology, 2017
Background: Although substantial evidence suggests that maternal work hours may have a negative effect on children’s cognitive development, the link between maternal work hours and children’s affect remains unclear.
Huan Zhou, Bo Lv, Xiaolin Guo, Chunhui Liu, Bing Qi, Weiping Hu, Weiping Hu, Zhaomin Liu, Liang Luo   +8 more
doaj   +1 more source

Firms' Main Market, Human Capital and Wages [PDF]

, 2009
Recent international trade literature emphasizes two features in characterizing the current patterns of trade: efficiency heterogeneity at the firm level and quality differentiation.
AB Bernard, AB Bernard, AB Bernard, AB Bernard, D Card, D Hummels, D Hummels, EA Verhoogen, F Alcalá, H Battu, H Flam, J Eaton, JJ Dolado, JR Munch, K Bayard, KM Murphy, KR Troske, L Fontagne, M Arai, M Baker, MJ Melitz, N Stokey, P Biscourp, P Manasse, P Schott, RE Falvey, S Yeaple, T Schank, TL Idson   +28 more
core   +7 more sources