Results 201 to 210 of about 3,540,976 (313)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Study Protocol: Psychometric Testing of the German Vestibular Schwannoma Quality of Life Index-A Multicenter Study on Quality of Life and Patient-Centered Care in Vestibular Schwannoma. [PDF]

Audiol Res
Rutenkröger M, Dührsen L, Scheer M, Krieg SM, Walter J, Baehr A, Baselt B, Huber A, Scholl I.   +8 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The Association Between Active Aging and Health-Related Quality of Life. [PDF]

Geriatrics (Basel)
Woo K, Lee J, Choy Y.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Quality of Care and Quality of Life: Convergence or Divergence?

Health Services Insights, 2014
Wadi B. Alonazi, Shane A. Thomas
doaj  

Symptom benchmarks of improved quality of life among military veterans with PTSD. [PDF]

J Mood Anxiety Disord
Schnurr PP, Lunney CA, Chard KM, Ruzek JI, Marx BP, Crow TM.   +5 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Comparing translations of the EORTC QLQ-C30 using differential item functioning analyses [PDF]

, 2010
Scott, NW;Fayers, PM;Bottomley, A;Aaronson, NK;de Graeff, A;Groenvold, M;Koller, M;Petersen, MA;Sprangers, MA;on behalf of the EORTC and the Quality of Life Cross-Cultural Meta-Analysis Group
core  

Quality of Life in Patients with Posterior Segment Eye Diseases. [PDF]

J Ophthalmic Vis Res
Khorrami-Nejad M, Narooie-Noori F, Al-Khafaji Q, Hashemian H, Balal S, Dohlman T, Daya S.   +6 more
europepmc   +1 more source