Results 41 to 50 of about 5,128,429 (317)

Using prior information to individualize start item selection when assessing physical functioning with the EORTC CAT Core

Health and Quality of Life Outcomes
Background Computerized adaptive test (CAT) provides individualized measurement, using the patient’s previous responses to select the next most informative item.
Morten Aa. Petersen, Hugo Vachon, Johannes M. Giesinger, Mogens Groenvold, on behalf of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group   +4 more
doaj   +1 more source

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source

A measurement based software quality framework [PDF]

, 2014
In this report we propose a solution to problem of the dependency on the experience of the software project quality assurance personnel by providing a transparent, objective and measurement based quality framework. The framework helps the quality assurance experts making objective and comparable decisions in software projects by defining and assessing ...
arxiv   +1 more source

Optimization of Software Quality Using Management and Technical Review Techniques [PDF]

Optimization of Software Quality using Management and Technical Review Techniques- International Journal of Computer Trends and Technology by IJCTTJournal Volume-17 Number-6 Year of Publication : 2014 Authors :Inibehe Emmanuel Akpannah, 2014
Optimizing the quality of software is a function of the degree of reviews made during the early life of a software development process. Reviews detect errors and potential errors early in the software development process. The errors detected during the early life cycle of software are least expensive to correct.
arxiv   +1 more source

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Terrestrial Life in Light of the Copernican Principle [PDF]

arXiv, 2023
Although many solar systems have been discovered, only one example of life is known. Thus, terrestrial life represents merely one data point. Consequently, extrapolating from terrestrial life to life elsewhere in the galaxy and beyond is often seen as a limitation in the search for different forms of life.
arxiv  

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

An evaluation of life satisfaction and health – Quality of life of senior citizens

Annals of Agricultural and Environmental Medicine, 2015
Introduction Modern medicine is still searching for the antecedents which will lead to [i]successful aging[/i]. The article discusses the self-perception of life satisfaction and health of senior citizens.
Artur Ziółkowski, Aleksandra Błachnio, Maria Pąchalska   +2 more
doaj   +1 more source