Results 91 to 100 of about 3,611,588 (270)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

A Methodology for Search Space Reduction in QoS Aware Semantic Web Service Composition [PDF]

arXiv, 2018
The semantic information regulates the expressiveness of a web service. State-of-the-art approaches in web services research have used the semantics of a web service for different purposes, mainly for service discovery, composition, execution etc. In this paper, our main focus is on semantic driven Quality of Service (QoS) aware service composition ...
arxiv  

Dimensions of service quality in healthcare: a systematic review of literature

International Journal for Quality in Health Care, 2019
PURPOSE Various dimensions of healthcare service quality were used and discussed in literature across the globe. This study presents an updated meaningful review of the extensive research that has been conducted on measuring dimensions of healthcare ...
Iram Fatima, A. Humayun, Usman Iqbal, Muhammad Imtiaz Shafiq   +3 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Assessing the maturity of software testing services using CMMI-SVC: An industrial case study [PDF]

arXiv, 2020
Context: While many companies conduct their software testing activities in-house, many other companies outsource their software testing needs to other firms who act as software testing service providers. As a result, Testing as a Service (TaaS) has emerged as a strong service industry in the last several decades.
arxiv  

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Calmodulin Gene Expression in Response to Mechanical Wounding and Botrytis cinerea Infection in Tomato Fruit

Plants, 2014
Calmodulin, a ubiquitous calcium sensor, plays an important role in decoding stress-triggered intracellular calcium changes and regulates the functions of numerous target proteins involved in various plant physiological responses.
Hui Peng, Tianbao Yang, Wayne M. Jurick II   +2 more
doaj   +1 more source

A broker-based framework for integrated SLA-aware SaaS Provisioning [PDF]

International Journal on Cloud Computing: Services and Architecture (IJCCSA) Vol. 6, No. 2, April 2016, 2016
In the service landscape, the issues of service selection, negotiation of Service Level Agreements (SLA), and SLA-compliance monitoring have typically been used in separate and disparate ways, which affect the quality of the services that consumers obtain from their providers.
arxiv  

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Equivalency of peroxyacetic acid to chlorine as a shell egg sanitizing rinse

Poultry Science, 2021
In the United States, all shell eggs processed under the USDA Agricultural Marketing Service voluntary grading standards must receive a shell sanitizing rinse of 100–200 ppm chlorine or its equivalent after leaving the washing process.
Deana R. Jones, Javier S. Garcia, Richard K. Gast, Garrett E. Ward   +3 more
doaj