Results 101 to 110 of about 5,280,661 (313)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

In Search of Optimum Fresh-Cut Raw Material: Using Computer Vision Systems as a Sensory Screening Tool for Browning-Resistant Romaine Lettuce Accessions

Horticulturae
The popularity of ready-to-eat (RTE) salads has prompted novel technology to prolong the shelf life of their ingredients. Fresh-cut romaine lettuce is widely used in RTE salads; however, its tendency to quickly discolor continues to be a challenge for ...
Ellen R. Bornhorst, Yaguang Luo, Eunhee Park, Bin Zhou, Ellen R. Turner, Zi Teng, Frances Trouth, Ivan Simko, Jorge M. Fonseca   +8 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

The impact of the COVID-19 pandemic on the surgical care continuum in Ethiopia: a national survey

BMC Health Services Research
Background The COVID-19 pandemic severely affected social welfare, the economy, and global health, making delivering even the essential health service impossible.
Amare Hailekiros Gebregzi, Berhane Redae Meshesha, Hassen Mohammed Beshir, Desalegn Bekele Taye, Fitalew Dagnew, Manuel K. Sibhatu, Amanuel Sisay Endeshaw, Fantahun Tarekegn Kumie   +7 more
doaj   +1 more source

Leveraging Observations of Untrained Panelists to Screen for Quality of Fresh-Cut Romaine Lettuce

Horticulturae
Fresh-cut romaine lettuce’s high perishability challenges ready-to-eat (RTE) salad production. Selecting cultivars less prone to browning and decay is crucial for extending shelf life.
Eunhee Park, Yaguang Luo, Ellen R. Bornhorst, Ivan Simko, Frances Trouth, Jorge M. Fonseca   +5 more
doaj   +1 more source

A New HPLC-ELSD Method for Simultaneous Determination of N-Acetylglucosamine and N-Acetylgalactosamine in Dairy Foods

International Journal of Analytical Chemistry, 2015
A rapid high performance liquid chromatographic method with evaporative light scattering detection (HPLC-ELSD), using a carbohydrate column, was developed for simultaneous determination of N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc ...
Ho Jin Kim, In Kyung Bae, Min Hee Jeong, Hye Jin Park, Jin Sil Jung, Jang Eok Kim   +5 more
doaj   +1 more source

Analysis of Influence Factor of Technology, Service Quality, and Customer Focus on Customer Satisfaction (Study on Buyer Products of Bandeng Juwana Elrina Semarang) [PDF]

, 2011
This study aims to determine the influence of factor of technology, service quality,andcustomer focus of the customer satisfaction on the Bandeng Juwana Elrina Group Semarang. Andthis research also aims to analyze the most dominant factors that influence
PH, Y. S. (Y), Telan, A. C. (Ariane)
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Impact of heat and high-moisture pH treatments on starch digestibility, phenolic composition, and cell bioactivity in sorghum (Sorghum bicolor L. Moench) flour

Frontiers in Nutrition
Sorghum (Sorghum bicolor L. Moench), characterized by substantial genetic diversity, encompasses some lines rich in health-promoting polyphenols. Laboratory studies have demonstrated anticancer properties of sorghum phenolics; however, their presence may
Jaymi Peterson, Adina L. Santana, Sarah Cox, Mayra Perez-Fajardo, Jose Covarrubias, Ramasamy Perumal, Scott Bean, Xiaorong Wu, Weiqun Wang, Dmitriy Smolensky   +9 more
doaj   +1 more source