Results 81 to 90 of about 3,611,588 (270)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

High Quality Requirement Engineering and Applying Priority Based Tools for QoS Standardization in Web Service Architecture [PDF]

open access: yesarXiv, 2013
Even though there are more development to improving the Quality of Service and requirement engineering in web services yet there is a big scarcity for its related standardization in day to day progress leading to vast needs in its area. Also in web service environment it always has been a big challenge to raise the standard of Quality of Service in ...
arxiv  

Repurchase Intention: The Effect of Service Quality, System Quality, Information Quality, and Customer Satisfaction as Mediating Role: A PLS Approach of M-Commerce Ride Hailing Service in Vietnam

open access: yes, 2018
This study employs DeLone and McLean’s information system success model to measure the effect of service quality, system quality, information quality on repurchase intention of the smartphone-based ride hailing service in Vietnam.
Nguyen Ngoc Duy Phuong   +1 more
semanticscholar   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

open access: yesMolecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren   +4 more
wiley   +1 more source

Re-evolution of Durum Wheat by Introducing the Hardness and Glu-D1 Loci

open access: yesFrontiers in Sustainable Food Systems, 2019
Durum wheat is an important crop worldwide. In many areas, durum wheat appears to have competitive yield, and biotic and abiotic advantages over bread wheat. What limits durum production? In one respect, the comparatively more limited processing and food
Craig F. Morris   +6 more
doaj   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

A Decision Tree Approach to Classify Web Services using Quality Parameters [PDF]

open access: yesarXiv, 2013
With the increase in the number of web services, many web services are available on internet providing the same functionality, making it difficult to choose the best one, fulfilling users all requirements. This problem can be solved by considering the quality of web services to distinguish functionally similar web services.
arxiv  

The effects of service quality and consumer-brand value congruity on hospitality brand loyalty

open access: yesAnatolia : An International Journal of Tourism and Hospitality Research, 2019
This research integrates the congruity and the social identity theories to better understand the consumer-brand relationships. A structural equation modelling approach was used to explore the drivers of brand loyalty in the context of upscale hotels. The
R. Rather, M. Camilleri
semanticscholar   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

A novel hydroxycinnamoyl transferase for synthesis of hydroxycinnamoyl spermine conjugates in plants

open access: yesBMC Plant Biology, 2019
Background Hydroxycinnamoyl-spermine conjugates (HCSpm) are a class of hydroxycinnamic acid amides (HCAAs), which not only are instrumental in plant development and stress response, but also benefit human health.
Hui Peng   +10 more
doaj   +1 more source

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