Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas+15 more
wiley +1 more source
High Quality Requirement Engineering and Applying Priority Based Tools for QoS Standardization in Web Service Architecture [PDF]
Even though there are more development to improving the Quality of Service and requirement engineering in web services yet there is a big scarcity for its related standardization in day to day progress leading to vast needs in its area. Also in web service environment it always has been a big challenge to raise the standard of Quality of Service in ...
arxiv
This study employs DeLone and McLean’s information system success model to measure the effect of service quality, system quality, information quality on repurchase intention of the smartphone-based ride hailing service in Vietnam.
Nguyen Ngoc Duy Phuong+1 more
semanticscholar +1 more source
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren+4 more
wiley +1 more source
Re-evolution of Durum Wheat by Introducing the Hardness and Glu-D1 Loci
Durum wheat is an important crop worldwide. In many areas, durum wheat appears to have competitive yield, and biotic and abiotic advantages over bread wheat. What limits durum production? In one respect, the comparatively more limited processing and food
Craig F. Morris+6 more
doaj +1 more source
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh+6 more
wiley +1 more source
A Decision Tree Approach to Classify Web Services using Quality Parameters [PDF]
With the increase in the number of web services, many web services are available on internet providing the same functionality, making it difficult to choose the best one, fulfilling users all requirements. This problem can be solved by considering the quality of web services to distinguish functionally similar web services.
arxiv
The effects of service quality and consumer-brand value congruity on hospitality brand loyalty
This research integrates the congruity and the social identity theories to better understand the consumer-brand relationships. A structural equation modelling approach was used to explore the drivers of brand loyalty in the context of upscale hotels. The
R. Rather, M. Camilleri
semanticscholar +1 more source
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi+26 more
wiley +1 more source
A novel hydroxycinnamoyl transferase for synthesis of hydroxycinnamoyl spermine conjugates in plants
Background Hydroxycinnamoyl-spermine conjugates (HCSpm) are a class of hydroxycinnamic acid amides (HCAAs), which not only are instrumental in plant development and stress response, but also benefit human health.
Hui Peng+10 more
doaj +1 more source