Results 111 to 120 of about 1,788,201 (258)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Relationship Between Professional Quality of Life and Work Alienation Among Healthcare Professionals

open access: yesFlorence Nightingale Journal of Nursing, 2021
Emel Gümüş   +3 more
doaj   +1 more source

Quality of Work Life Amongst Nurse Professionals: A Concept Analysis. [PDF]

open access: yesInt J Environ Res Public Health
Fonseca MC   +10 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

An Occupational Health Perspective of Nurses’ Quality of Life in Indonesia

open access: yesSocial Medicine
This study aims to develop factors and indicators of aspects that shape nurses' quality of life. It was conducted using a cross-sectional design, while the population consisted of nurses working in the inpatient ward totaling 915.
Nuraini   +3 more
doaj  

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