Results 161 to 170 of about 9,296,950 (308)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Current Landscape of Curriculum Development and Implementation in Medical Artificial Intelligence: A Scoping Review. [PDF]
J Multidiscip HealthcWang Y, Wang H, Wang T, Ye X, Mao R.
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Participation in Conservation Programs by Targeted Farmers: Beginning, Limited-Resource, and Socially Disadvantaged Operators' Enrollment Trends [PDF]
Beginning, limited-resource, and socially disadvantaged farmers make up as much as 40 percent of all U.S. farms. Some Federal conservation programs contain provisions that encourage participation by such “targeted” farmers and the 2008 Farm Act furthered
Hand, Michael S., Nickerson, Cynthia J.
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
MuscleExpert: a semi-automated tool delivering ImageJ-comparable measurements of muscle thickness, area, and quality. [PDF]
PeerJLi Z, Zhang LQ, Lanza MB.
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Core Elements of the Stunting Prevention Model to Improve Adolescents' Quality of Life. [PDF]
J Multidiscip HealthcHutasoit ES +3 more
europepmc +1 more source
NATIONAL "E-EXTENSION" PROGRAMS: FEASIBILITY AND STRUCTURE [PDF]
Illinois agriculture and natural resource e-Extension programs have exceeded expectations. National e-Extension programs will also succeed given they explicitly help clients make decisions, make available user-friendly decision tools and data, use GIS ...
White, Carolyn +2 more
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