Results 141 to 150 of about 4,550,276 (301)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Professional discourse, quality assurance and a practice integrated pre-service teacher education course: The Open University PGCE

, 2007
The Open University (UK) Postgraduate Certificate in Education (PGCE) programme is a distance learning pre-service course in teacher education which integrates learning in the practice setting with university-based learning.
Hutchinson, Steven
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

BUILDING DETERMINISTIC MODELS OF PRODUCT QUALITY DYNAMICS

Вестник Донского государственного технического университета, 2018
The deterministic models of the product quality dynamics based on the theoretical basics of the material systems kinetics are built. The dependence of the product quality change from the production complexity, resistance factors and requirements of ...
Alexander G. Ivakhnenko, Vadim E. Puzanov   +1 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Determining quality requirements at the universities to improve the quality of education

Хабаршысы. Экономика сериясы, 2018
In this study the information was given regarding Kano’s Model and a case study was conducted for university students. Kano’s Model was applied for Akhmet Yassawi University students and it was questioned what they thought were important quality ...
Н. Мустафа, Д. Келесбаев, Ж. Алибекова   +2 more
doaj  

Quality Requirements for Electronic Health Record Systems*. A Japanese-German Information Management Perspective. [PDF]

Methods Inf Med, 2017
Winter A, Takabayashi K, Jahn F, Kimura E, Engelbrecht R, Haux R, Honda M, Hübner UH, Inoue S, Kohl CD, Matsumoto T, Matsumura Y, Miyo K, Nakashima N, Prokosch HU, Staemmler M.   +15 more
europepmc   +1 more source

Does Teacher Testing Raise Teacher Quality? Evidence from State Certification Requirements [PDF]

The education reform movement includes efforts to raise teacher quality through stricter certification and licensing provisions. Most US states now require public school teachers to pass a standardized test such as the National Teacher Examination ...
Jonathan Guryan, Joshua D. Angrist
core