Results 101 to 110 of about 2,871,062 (264)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Impact of different treatment methods and timings on soil microbial communities with transgenic maize straw return

Scientific Reports
Understanding the impact of genetically modified (GM) crop straw return on soil ecosystems is crucial as GM crops become more prevalent. This study assesses the effects of straw mulching and deep tillage on soil microbial communities from GM and non-GM ...
Yanbo Xie, Jun-Yan Xiang, Likun Long, Yue Ma, Zhenjuan Xing, Ling Wang, Chunyu Shao, Na Liu, Feiwu Li   +8 more
doaj   +1 more source

Cancer prevales on COVID-19: To maintain high quality standard concerning diagnosis and oncological care even during a pandemic. [PDF]

J Med Virol, 2021
Giuliani J, Bonetti A.
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Unveil the molecular recognition mechanisms of triazine haptens and monoclonal antibodies: Establishing ic‐ELISA methods for triazine herbicide analysis in tea

Food Safety and Health
This study introduced two triazine haptens (with 0 or 1 carbon connecting arms at nonisopropyl positions) and developed two heterologous indirect competitive enzyme‐linked immunosorbent assay (ic‐ELISA) methods.
Lingyuan Xu, A. M. Abd El‐Aty, Peipei Li, Jia Li, Jing Zhao, Xingmei Lei, Song Gao, Yun Zhao, Yongxin She, Fen Jin, Jing Wang, Bruce D. Hammock, Maojun Jin   +12 more
doaj   +1 more source

Clinical quality standards for radiotherapy

Współczesna Onkologia, 2012
The technological progress that is currently being witnessed in the areas of diagnostic imaging, treatment planning systems and therapeutic equipment has caused radiotherapy to become a high-tech and interdisciplinary domain involving staff of various backgrounds.
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Global Quality Standard for Identification and Management of Severe Asthma. [PDF]

Adv Ther, 2020
Haughney J, Winders TA, Holmes S, Chanez P, Saul H, Menzies-Gow A, PRECISION Improve Access to Better Care Task Force.   +6 more
europepmc   +1 more source