Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Standards vs. labels with imperfect competition and asymmetric information [PDF]
I demonstrate that providing information about product quality is not necessarily the best way to address asymmetric information problems when markets are imperfectly competitive.
Kenneth Baltzer
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
FoodsTo achieve rapid screening and semi-quantitative analysis of pesticide residues in mobile laboratories and on-site tea testing, a novel method based on thermal-assisted plasma ionization–time-of-flight mass spectrometry (TAPI-TOF/MS) has been developed ...
Jiangsheng Mao +7 more
doaj +1 more source
Quality Objectives in Standardized Quality Management Systems
Quality Management in Health CareBackground and Objectives: The effectiveness of a quality management system consistent with the ISO 9001 standard depends on how quality objectives are established and pursued. The aims of this article are to identify quality objectives in selected certified organizations providing medical services, assess their compliance with
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Cancer prevales on COVID-19: To maintain high quality standard concerning diagnosis and oncological care even during a pandemic. [PDF]
J Med Virol, 2021 Giuliani J, Bonetti A.
europepmc +1 more source
LIVING STANDARD, QUALITY OF LIFE IN NORTH-EAST HUNGARY BASED ON A SURVEY [PDF]
living standard, quality of life, liveability, North-East Hungary, regional differences, questionnaire surveyliving standard, quality of life, liveability, North-East Hungary, regional differences, questionnaire survey, Community/Rural/Urban Development,
Kiraly, Zsolt, Takacs, Istvan
core +1 more source
Building a compliance audit for BS7988 “Code of practice for the use of information technology (IT) in the delivery of assessments” [PDF]
, 2002 The BS7988 standard is now formally published, and is broadly in line with the provisional specification presented by John Kleeman, David Keech and Stephen Wright to this conference last year.
Grove-Stephenson, Ian +2 more
core
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source