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Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Benchmarking newborn care quality in Ghana: Evidence from structured observations of clinical practice against WHO quality standards. [PDF]
Salia SM +3 more
europepmc +1 more source
Deep learning models to predict mammographic density jointly on standard dose and low dose images. [PDF]
Squires S +4 more
europepmc +1 more source
Contraindications of femoral implants in primary total hip arthroplasty : legal implications and strategies for orthopaedic surgeons. [PDF]
Manzo MA +3 more
europepmc +1 more source
Clinical evaluation of deep learning accelerated 3D magnetic resonance cholangiopancreatography at 1.5 T and 3 T. [PDF]
Jambor I +14 more
europepmc +1 more source
Efficacy and safety of vitamin D in the treatment of asthma: an overview of systematic reviews and meta-analyses. [PDF]
Liu Y +8 more
europepmc +1 more source
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Time to add screening for financial hardship as a quality measure?
Ca-A Cancer Journal for Clinicians, 2021Cathy J Bradley +2 more
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