Results 261 to 270 of about 20,192,591 (347)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Employment quality and mortality in Canada. [PDF]

J Epidemiol Community Health
Shahidi FV, Andreacchi AT, Fuller AE, Blair A, Carnide N, Harris MA, Pabayo R, Smith B, Siddiqi A, Smith P.   +9 more
europepmc   +1 more source

Environmental quality shapes the fitness payoffs of multiple paternity. [PDF]

BMC Ecol Evol
Darmis F, Guenther A.
europepmc   +1 more source

Study on nutritional status and incidence of sarcopenia in elderly patients with chronic heart failure. [PDF]

Asia Pac J Clin Nutr
Song S, Du H, Lu X, Luo B, Li Z.
europepmc   +1 more source

Capturing Optimal Mobile 2D Facial Images in Remote Aesthetics Medicine Clinical Trials: Technical Considerations for Facial Severity Analysis. [PDF]

JMIR Form Res
Caiazza D, Kreutzkamp S.
europepmc   +1 more source

Impact of SAAC accreditation on laboratories in Saudi Arabia according to ISO/IEC 17025:2017. [PDF]

Sci Rep
Alomair A, Alfayez M, Abuhaimed M, Alrabeh M.   +3 more
europepmc   +1 more source

MGDB: A Novel Bioinformatics Quality Control Tool for Clinical Next-Generation Sequencing. [PDF]

Cancer Inform
Gayap HT, Robichaud PP, Crapoulet N, Allain EP.   +3 more
europepmc   +1 more source