Results 111 to 120 of about 1,899,364 (316)

An on-line solid phase extraction procedure for the routine quantification of urinary methylmalonic acid by liquid chromatography-tandem mass spectrometry [PDF]

open access: yes, 2010
Background: The goal of this study was to develop and to validate an improved isotope-dilution-liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of methylmalonic acid (MMA) in urine.
Michael Vogeser   +5 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

New Studies of Space and Quantification in Languages of China [PDF]

open access: yes, 2015
International audienceSpace and quantification are among the most fundamental concepts expressed in the world’s languages. They are central to human activities and therefore find their way into languages.
Xu, Dan
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Inferences in context : contextualism, inferentialism and the concept of universal quantification [PDF]

open access: yes, 2009
This Thesis addresses issues that lie at the intersection of two broad philosophical projects: inferentialism and contextualism. It discusses and defends an account of the logical concepts based on the following two ideas: 1) that the logical concepts ...
Tabet, Chiara
core  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Molecular quantification in digital health diagnostic cd with surface modifications [PDF]

open access: yes, 2011
This thesis aims to document the experimental quantification of molecules on top of a common compact disc (CD) using the ubiquitous and inexpensive technology of a CD drive.
Majeed, Hassaan
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Quantification of Biophysical Parameters in Medical Imaging [PDF]

open access: yes
The second edition of this book offers six new chapters covering the latest developments in quantitative medical imaging, including artificial intelligence, MRI mapping, sonography, elastography and cardiac CT.

core   +1 more source

Ethics of quantification or quantification of ethics?

open access: yesFutures, 2020
Abstract Something can be gained by looking at common ethical features of different instances of quantification. While ethics of algorithms is perceived at present as an urgent issue, similar concerns can easily be associated to the use of metrics, of statistical inference, and of mathematical modelling. By reviewing these common features, strategies
openaire   +3 more sources

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