Results 201 to 210 of about 5,048,446 (317)

Simple, fast, reliable: multiplex digital PCR quantification of 19 genetically modified soybean events. [PDF]

GM Crops Food
Jelenčič A, Štebih D, Demšar T, Dobnik D.   +3 more
europepmc   +1 more source

Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems.

Journal of Molecular Endocrinology, 2002
S. Bustin
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Type and Size of Fluorescent Proteins Modulate the Localization of PTEN and Its Fragments, but Have Little or No Effect on Mutant PTEN or Stressed Cells. [PDF]

J Histochem Cytochem
Kato T, Kawakami Y.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Influence of Basis Set Composition on Metabolite Quantification of ¹H-MRS at 3 T: Combining In Silico, In Vivo and In Vitro Evidence. [PDF]

NMR Biomed
Emeliyanova P, Parkes LM, Lea-Carnall C, Williams SR.   +3 more
europepmc   +1 more source

Variance stabilization applied to microarray data calibration and to the quantification of differential expression

Intelligent Systems in Molecular Biology, 2002
W. Huber, A. Heydebreck, H. Sültmann, A. Poustka, M. Vingron   +4 more
semanticscholar   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Ginkgolic acid targets HSPA8 to trigger ferroptosis in hepatocellular carcinoma <i>via</i> chaperone-mediated autophagy-dependent GPX4 degradation. [PDF]

Pharm Biol
Liu R, Zhang Y, Zou H, Zhang M, Yang Z, Liao K, Wang G, Liu B, Tang L, Kang X, Zheng S.   +10 more
europepmc   +1 more source

A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia. [PDF]

Nat Commun
Mirfakhar FS, Marsh JA, Sato C, Schache KJ, Minaya MA, Dolle RE, Pak SC, Silverman GA, Perlmutter DH, Macauley SL, Karch CM.   +10 more
europepmc   +1 more source