Results 251 to 260 of about 5,048,446 (317)

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Enzymes of physiological amyloidogenesis control pathological amyloid toxicity. [PDF]

Life Sci Alliance
Bokros M, Grunfeld A, Balukoff NC, Bouviere J, Beurel E, Lee S.   +5 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Understanding the qPCR Standard Curve: From Assay Validation to Absolute Quantification and Variance PCR. [PDF]

Int J Mol Sci
Kubista M, Forootan A, Pfaffl MW, Bustin SA, Andrade JM, Sjöback R, Sjögreen B, Ståhlberg A.   +7 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Oligodendrocyte Precursor Cells Shape Retinogeniculate Refinement Via a CHD8-Dependent Phagocytic Pathway. [PDF]

Invest Ophthalmol Vis Sci
Wen S, Guo F, Li Z, Huang G, Shen M, He X.   +5 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Primary human intestinal organoids model enteric infection of monkeypox virus and enable scalable drug discovery. [PDF]

Sci Adv
Li P, Wang X, Zhou J, Yao Y, Wang Y, Xu G, Schraauwen R, da Silva AMG, de Henau C, Incitti R, Offermans DM, de Vries AC, Kainov DE, Alam I, Raymond K, Duarte-Neto AN, Bijvelds MJC, Pan Q.   +17 more
europepmc   +1 more source

Correction to “Altered splicing of ATG16‐L1 mediates acquired resistance to tyrosine kinase inhibitors of EGFR by blocking autophagy in non‐small cell lung cancer”

Molecular Oncology, EarlyView.
wiley   +1 more source

Elevated Kallistatin Induces Myosteatosis and Exercise Intolerance by Antagonizing AdipoR1-Mediated AMPK Signalling. [PDF]

J Cachexia Sarcopenia Muscle
Hong F, Fang Z, Shen G, Wang Y, Li Y, Zhong Y, Dai J, Zhang C, Zhang J, Chen W, Qi W, Yang X, Gao G, Zhou T.   +13 more
europepmc   +1 more source