Results 111 to 120 of about 129,657 (289)
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Acquisition of L2 English Negative Quantifiers without Equivalent Lexical Items in an L1
Theory and Practice of Second Language AcquisitionThis article investigates how second language learners interpret a scope bearing item in the target language. According to Sprouse (2006), L2 learners’ task is to relabel their native language’s lexical items in line with the features of the target ...
Masaaki Kamiya, Zhaosen Guo
doaj +1 more source
Quantifying residual finiteness
Journal of Algebra, 2010 We introduce the concept of quantifying the extent to which a finitely generated group is residually finite. The quantification is carried out for some examples including free groups, the first Grigorchuk group, finitely generated nilpotent groups, and certain arithmetic groups such as $SL_n(\mathbb{Z})$.
openaire +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Bucharest Working Papers in Linguistics, 2009 The paper contrasts the exceptive constructions containing the particle decât in Romanian, namely nu…decât and nu…alt+ceva/cineva decât, considering the semantic and syntactic properties of these two constructions against the background of the analysis ...
Nicoleta Sava
doaj
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Ìнформаційні технології в освіті, 2009 This article presents the PM ‘Solving environment’ of integrated programmatic environment Mathlogic v.2, (ML2) which was made within the framework of project of Terra Mathematica in the Laboratory of Pedagogical Software Development and Implementation ...
O. V. Scherbina +2 more
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Quantifying over Quantifiers (Abstract)
Electronic Notes in Theoretical Computer ScienceAbstractWe study existential and universal quantification over quantifiers, i.e. quantification where the objects quantified over are Lindstrom quantifiers. First we consider the fragment where only existential quantification over quantifiers is allowed, denoted ΣQ1.
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