Results 211 to 220 of about 206,054 (294)

Tracing the origins and evolution of nymphalid butterflies (Lepidoptera) in the Atlantic Forest

open access: yesEcography, EarlyView.
Understanding the relative roles of diversification and dispersal is key to explaining large‐scale biogeographical patterns. Although both processes are known to shape biodiversity, their relative contributions remain understudied for many organisms. Here, we examine how these processes have jointly contributed to the exceptional diversity and endemism
Mar Repullés   +7 more
wiley   +1 more source

A Novel Multilevel Conceptual Framework for Flood Risk Governance

open access: yesEnvironmental Policy and Governance, EarlyView.
ABSTRACT Globally, flood risk is increasing as climate change progresses. Contemporary flood risk management practice often utilises hydrodynamic modelling (for hazard risk assessments), social vulnerability assessments, and risk communications in silo, which fragments evidence‐based decision‐making for effective flood risk management. We hence develop
Aiperi Stambekova, Avidesh Seenath
wiley   +1 more source

Decoding epilepsy's molecular blueprint: Machine learning unravels transcriptomic subtypes and regulatory networks

open access: yesEpilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy. The molecular heterogeneity underlying DRE remains poorly defined, largely due to limited access to resected brain tissue and substantial genetic diversity.
Yanping Weng   +11 more
wiley   +1 more source

Tissue oxygenation dynamics during transition from seizure to spreading depolarization in rat brain

open access: yesEpilepsia, EarlyView.
Abstract Objective Spreading depolarization (SD) is a phenomenon underlying various neurological conditions, including epilepsy. Researchers have suspected that local tissue oxygenation breakdown induces spontaneous SD. In this study, we investigated the relationship between spontaneous epileptic seizures and SD, with a focus on the role of local ...
Jiayang Liu, Bruce J. Gluckman
wiley   +1 more source

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

open access: yesEpilepsia, EarlyView.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley   +11 more
wiley   +1 more source

Stereo‐EEG mapping of visual working memory with task‐related high‐gamma modulations

open access: yesEpilepsia, EarlyView.
Abstract Objective We describe a safe, informative, and easy‐to‐implement approach for presurgical mapping of visual working memory (VWM) with stereo‐electroencephalography (SEEG). Methods Twenty‐four patients with drug‐resistant epilepsy, 11–23 years of age, performed a single‐probe change detection VWM task, during SEEG monitoring.
Brian Ervin   +13 more
wiley   +1 more source

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