Results 141 to 150 of about 3,032,172 (354)

Population pharmacokinetics and exposure–response analysis of durvalumab in patients with resectable stage II to IIIB (N2) NSCLC in the phase III AEGEAN study

British Journal of Clinical Pharmacology, EarlyView.
Aims In the AEGEAN study, perioperative durvalumab plus platinum‐based neoadjuvant chemotherapy for patients with resectable stage II to IIIB (N2) non‐small‐cell lung cancer (NSCLC) demonstrated a favourable benefit–risk profile. This study evaluated population pharmacokinetics (PopPK) and exposure–response (ER) relationships of durvalumab in patients ...
Xiaoying Zhao, Junjie Ding, Jiajia Zhao, Ling Zhang, Aburough Abegesah, Yu‐qian Zhang, Cathy O'Brien, Gary J. Doherty, Allen C. Chen, KyoungSoo Lim, Song Ren, Peiming Ma, Diansong Zhou   +12 more
wiley   +1 more source

Unlocking the investment nexus between artificial intelligence and Bitcoin: Modified cross-quantile regression insights

Social Sciences and Humanities Open
In recent years, cryptocurrencies have emerged as a prime digital currency and an important asset, and the financial system is emerging as an important aspect while artificial intelligence (AI) has advanced expeditiously.
Seyed Alireza Athari, Dervis Kirikkaleli, Chafic Saliba, Victoria Olushola Olanrewaju   +3 more
doaj   +1 more source

Quantile Regression in Risk Calibration [PDF]

Financial risk control has always been challenging and becomes now an even harder problem as joint extreme events occur more frequently. For decision makers and government regulators, it is therefore important to obtain accurate information on the ...
Shih-Kang Chao, Weining Wang, Wolfgang Karl Härdle   +2 more
core  

An open‐label, single‐arm, dose‐escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack of association between paroxetine and corrected QT interval (QTc) prolongation is limited. Therefore, this
Sven C. van Dijkman, Mathieu Félices, Bhaskar Pandurangavittal, Sanman Ghorpade, Caroline Easterbrook, Marcin Zabielski, Oscar Della Pasqua   +6 more
wiley   +1 more source

The spread of non‐native species

Biological Reviews, EarlyView.
ABSTRACT The global redistribution of species through human agency is one of the defining ecological signatures of the Anthropocene, with biological invasions reshaping biodiversity patterns, ecosystem processes and services, and species interactions globally.
Phillip J. Haubrock, Ali Serhan Tarkan, Irene Martín‐Forés, Stelios Katsanevakis, Ronaldo Sousa, Ismael Soto, Andy J. Green, Antonín Kouba, Teun Everts, Victoria Dominguez Almela, Nadège Belouard, Cang Hui, Jamie Bojko, Victor Deklerck, Margaux Boeraeve, Franz Essl, J. Robert Britton   +16 more
wiley   +1 more source

Board Characteristics and Climate Commitment: A Comprehensive Analysis Unraveling Linear and Nonlinear Relationships

Business Strategy and the Environment, EarlyView.
ABSTRACT In an era of increasing environmental awareness, this study analyzes the relationship between board characteristics and corporate climate commitment across various industries. Our empirical analysis examines a comprehensive dataset that includes 4027 firms from the United States and Canada over the period from 2010 to 2022 and employs panel ...
Ines Ben Mehrez, Aymen Ajina, Amel Farhat   +2 more
wiley   +1 more source

Cash flow and financial distress of private listed enterprises on the Vietnam stock market: A quantile regression approach

, 2022
Thuy Duong Phan, Thi Thanh Hoang, Ngoc Mai Tran   +2 more
openalex   +2 more sources

Does ESG Investing Pay off? Comparing the Performance of ESG and Traditional ETFs Across European and US Markets

Business Strategy and the Environment, EarlyView.
ABSTRACT Investors have long recognized the importance of firms in promoting sustainability, leading to the rise of socially responsible investment (SRI). Specifically, there is a growing preference for exchange‐traded funds (ETFs) that prioritize environmental, social, and governance (ESG) principles.
Sandra Tenorio‐Salgueiro, Andrea Martínez‐Salgueiro, Rubén Lado‐Sestayo, Milagros Vivel‐Búa   +3 more
wiley   +1 more source

Inference for extremal conditional quantile models, with an application to market and birthweight risks [PDF]

Quantile regression is an increasingly important empirical tool in economics and other sciences for analyzing the impact of a set of regressors on the conditional distribution of an outcome. Extremal quantile regression, or quantile regression applied to
Iván Fernández-Val, Victor Chernozhukov   +1 more
core  

The ESG Emissions Paradox: Capability‐Contingent Effects of Research and Development and Cost Leadership in Asia

Business Strategy and the Environment, EarlyView.
ABSTRACT This study investigates the impact of greenhouse gas (GHG) emissions, research and development (R&D) spending, and cost leadership strategies (CLSs) on the environmental, social, and governance (ESG) performance of Asian firms from 2015 to 2023.
Mirza Muhammad Naseer, Nazim Hussain, Sana Akbar Khan, Giuseppe Nicolò   +3 more
wiley   +1 more source