Results 181 to 190 of about 3,500,762 (306)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Dynamic ultrasound enables quantitative assessment of medial knee instability: A scoping review. [PDF]

J Exp Orthop
Szeles PRQ, Ramos LA, Yamada AF, Cohen M, Sayers M, Ejnisman B.   +5 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Quantitative assessment of human-exoskeleton integration through a neurophysiological marker of embodiment. [PDF]

Sci Rep
Bertuccelli M, Tortora S, Pasinato M, Trombin E, Tasinazzo W, Baba A, Bisiacchi P, Sparacino G, Menegatti E, Del Felice A.   +9 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Quantitative assessment of light discomfort thresholds in a patient with photoallodynia treated with topical naltrexone 0.01. [PDF]

Am J Ophthalmol Case Rep
Lixi F, Coco G, Calabresi V, Vitiello L, Corda C, Verdiglione M, Costa S, Giannaccare G.   +7 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Quantitative Assessment of Forest Ecosystem Integrity and Authenticity Based on Vegetation in Hanma and Huzhong Reserves. [PDF]

Plants (Basel)
Wu X, Cao J, Yang K, Gao M, Liu Y.
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Inter- and Intrarater Reliability of a Novel Ultrasound Doppler Device (earlybird) for Quantitative Assessment of Peripheral Arterial Flow. [PDF]

Med Devices (Auckl)
Høiberg MT, Kvamme SMP, Bentsen SF, Løkken K, Rohde G, Torp H, Seternes A, Pettersen EM.   +7 more
europepmc   +1 more source