Results 241 to 250 of about 28,160,752 (309)
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court +3 more
wiley +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
, 2018 There are two main research approaches, namely qualitative and quantitative research.(de Vos et al.,2011).Each of these paradigm of methodology differ incisively in terms of inquiry method, collecting strategy for data, analysis, and quality judging ...
amankwa, E (via Mendeley Data)
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Proceedings of the 1975 ACM SIGMOD international conference on Management of data - SIGMOD '75, 1975
Quantitative descriptions of data populations have played an important role in the data base design process, particularly where simulation has been employed. The new levels of fidelity and representation-independence made possible by recent advances in data description languages warrant a renewed interest in this technique.
L. S. Schneider, C. R. Spath
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Quantitative descriptions of data populations have played an important role in the data base design process, particularly where simulation has been employed. The new levels of fidelity and representation-independence made possible by recent advances in data description languages warrant a renewed interest in this technique.
L. S. Schneider, C. R. Spath
openaire +1 more source
Strategies for quantitation of phosphoproteomic data
Expert Review of Proteomics, 2010Recent developments in phosphoproteomic sample-preparation techniques and sensitive mass spectrometry instrumentation have led to large-scale identifications of phosphoproteins and phosphorylation sites from highly complex samples. This has facilitated the implementation of different quantitation strategies in order to study the biological role of ...
Palmisano, Giuseppe +1 more
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2020
Quantitative research is first and foremost concerned with the measuring, indeed, the quantification of the object of study. However, quantifying observed phenomena of our social world, such as segregation, is not merely a particular way of measuring that differs from (and complements) other ways of measuring, which are placed in the ‘qualitative ...
openaire +1 more source
Quantitative research is first and foremost concerned with the measuring, indeed, the quantification of the object of study. However, quantifying observed phenomena of our social world, such as segregation, is not merely a particular way of measuring that differs from (and complements) other ways of measuring, which are placed in the ‘qualitative ...
openaire +1 more source
Questionnaires to Elicit Quantitative Data
2022The questionnaire has a long tradition of being employed as an instrument of attitude elicitation and has, as such, ‘attained a high level of sophistication and formal development’ (Agheyisi and Fishman 1970: 147). It has become one of the most frequently used methods in the study of language attitudes.
openaire +2 more sources