Results 81 to 90 of about 47,389 (255)

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source

Slowing of EEG background activity in Parkinson´s and Alzheimer´s Disease with early cognitive dysfunction

Frontiers in Aging Neuroscience, 2014
Background: Slowing of the electroencephalogram (EEG) is frequent in Parkinson’s (PD) and Alzheimer’s Disease (AD) and correlates with cognitive decline.
Nina eBenz, Florian eHatz, Habib eBousleiman, Michael eEhrensperger, Ute eGschwandtner, Martin eHardmeier, Stephan eRüegg, Christian eSchindler, Ronan eZimmermann, Andreas Urs Monsch, Peter eFuhr   +10 more
doaj   +1 more source

Stiripentol: Unpublished results from the first phase 2 clinical trial in Lennox–Gastaut syndrome conducted in the early 1990s

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to present the results of an exploratory phase 2 trial of stiripentol in Lennox–Gastaut syndrome (LGS). Methods This exploratory single‐blind, single‐arm, nonrandomized sequential‐period phase 2 study was conducted at four centers in France between January 1989 and August 1993.
Stéphane Auvin, Benjamin Serraz, Jérémie Lespinasse, Laurent Chancharme   +3 more
wiley   +1 more source

Lactate receptor HCAR1 in neonatal hypoxic–ischemic seizures

Epilepsia, EarlyView.
Abstract Hydroxycarboxylic acid receptor 1 (HCAR1) is a G‐protein‐coupled lactate receptor expressed in the brain and plays a role in neuronal excitability and repair after injury. Hypoxic–ischemic encephalopathy (HIE) is the most common cause of brain injury and seizures in term neonates.
Jennifer Burnsed, Angelina June, Maria Marlicz, Emmy Zucker, Ellie Kain‐Kuzniewski, Hannah Mulhern, Leanne Maharaj, John Williamson, Chengsan Sun, Suchitra Joshi, Huayu Sun, Jaideep Kapur   +11 more
wiley   +1 more source

Exploratory quantitative EEG characteristics in children with autism spectrum disorder

Frontiers in Psychiatry
IntroductionAutism Spectrum Disorders (ASD) are currently one of the most common childhood conditions. It is estimated that they affect approximately 1 in 31 children.
Marta Kopańska, Marta Kopańska, Danuta Ochojska, Danuta Ochojska, Izabela Sarzyńska, Izabela Sarzyńska, Julia Trojniak, Jacek Szczygielski, Jacek Szczygielski, Jacek Szczygielski   +9 more
doaj   +1 more source

Resting-state quantitative electroencephalography reveals increased neurophysiologic connectivity in depression.

PLoS ONE, 2012
Symptoms of Major Depressive Disorder (MDD) are hypothesized to arise from dysfunction in brain networks linking the limbic system and cortical regions.
Andrew F Leuchter, Ian A Cook, Aimee M Hunter, Chaochao Cai, Steve Horvath   +4 more
doaj   +1 more source

Integrating Artificial Intelligence with Real-time Intracranial EEG Monitoring to Automate Interictal Identification of Seizure Onset Zones in Focal Epilepsy

, 2018
An ability to map seizure-generating brain tissue, i.e., the seizure onset zone (SOZ), without recording actual seizures could reduce the duration of invasive EEG monitoring for patients with drug-resistant epilepsy.
Berry, Brent, Brinkmann, Benjamin, Cimbalnik, Jan, Iyer, Ravishankar, Kremen, Vaclav, Stead, Matt, Van Gompel, Jamie, Varatharajah, Yogatheesan, Worrell, Gregory   +8 more
core   +1 more source

Spatial transcriptomics in epilepsy research: Early successes, opportunities, and challenges

Epilepsia, EarlyView.
Donald J. Phillips, Autumn S. Ivy, Samuel Guzman, Saman Hazany, Xiangmin Xu   +4 more
wiley   +1 more source

Apathy in Patients with Parkinson's Disease Correlates with Alteration of Left Fronto-Polar Electroencephalographic Connectivity

Frontiers in Aging Neuroscience, 2017
Introduction: Quantitative electroencephalography (QEEG) brain frequency and network analyses are known to differentiate between disease stages in Parkinson's disease (PD) and are possible biomarkers. They correlate with cognitive decline.
Florian Hatz, Antonia Meyer, Ronan Zimmermann, Ute Gschwandtner, Peter Fuhr   +4 more
doaj   +1 more source

Complex Independent Component Analysis of Frequency-Domain Electroencephalographic Data

, 2003
Independent component analysis (ICA) has proven useful for modeling brain and electroencephalographic (EEG) data. Here, we present a new, generalized method to better capture the dynamics of brain signals than previous ICA algorithms.
Amari, Anemüller, Arieli, Bell, Berger, Bloomfield, Courchesne, Enghoff, Freeman, Hyvärinen, Jung, Jörn Anemüller, Kuhn, Lopez da Silva, Makeig, Makeig, Makeig, Makeig, Makeig, Nikias, Scott Makeig, Stein, Terrence J. Sejnowski, Torkkola, Zibulevsky   +24 more
core   +5 more sources