Results 121 to 130 of about 431,895 (247)

A Dynamic Double‐Flow Gut‐On‐Chip Model for Predictive Absorption Studies In Vitro

Advanced Materials Technologies, EarlyView.
This study presents a novel millifluidic gut‐on‐chip model using the MIVO® device to replicate human intestinal conditions. Dynamic co‐culture of CaCo‐2 and HT‐29 cells accelerates differentiation, modulates mucus thickness, and enhances barrier function.
Maria Elisabetta Federica Palamà, Maurizio Aiello, Gergő Borka, Jacopo Furci, Ilaria Parodi, Giuseppe Firpo, Silvia Scaglione   +6 more
wiley   +1 more source

Optimizing Metamaterial Inverse Design with 3D Conditional Diffusion Model and Data Augmentation

Advanced Materials Technologies, EarlyView.
A generative AI model, the 3D conditional diffusion model (3D‐CDM), is introduced to enhance the inverse design of voxel‐based metamaterials. A data augmentation technique based on topological perturbation expands the dataset, further improving generation quality and accuracy.
Xiaoyang Zheng, Junichiro Shiomi, Takayuki Yamada   +2 more
wiley   +1 more source

Picomolar Detection of Tau Protein Using 1D Photonic Crystal Biochips for Alzheimer's Disease Diagnosis

Advanced Sensor Research, EarlyView.
Elevated levels of Tau in cerebrospinal fluids or other body fluids are associated with the progression of Alzheimer's disease. An optical technique, based on a dual label‐free and fluorescence operation mode, is developed to detect Tau protein in both standard running buffer and cerebrospinal fluid.
Alberto Sinibaldi, Francesco Chiavaioli, Agostino Occhicone, Norbert Danz, Peter Munzert, Francesco Baldini, Ambra Giannetti, Francesco Michelotti   +7 more
wiley   +1 more source

Biomedical Application of Cold Plasma: Navigating Through Plasma Types and Devices by Antimicrobial Effectiveness and Tissue Tolerance

Advanced Therapeutics, EarlyView.
Cold plasma devices (J‐Plasma, Piezo Brush PZ3, Plasma Care) generate unique reactive species that penetrate tissues differently, enabling biofilm eradication while preserving tissue health. This study uncovers plasma‐device interactions with biofilms and surfaces, highlighting tailored applications for precision medicine and infection control ...
Thomas P. Thompson, Amanda Connelly, Sean Kelly, Ross M. Duncan, Jordanne‐Amee Maybin, Carla McDonnell, Autumn Melvage, Laura A. McClenaghan, Aikaterini Dedeloudi, Dimitrios A. Lamprou, Thomas P. Schaer, Paula Bourke, Noreen J. Hickok, Brendan F. Gilmore, Theresa A. Freeman   +14 more
wiley   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Interpretable Machine‐Learning and Big Data Mining to Predict the CO2 Separation in Polymer‐MOF Mixed Matrix Membranes

Advanced Science, EarlyView.
To explore the structure‐property relationships of MMM (Mixed Matrix Membranes), the big data mining is employed and a transfer learning model is trained for predicting and selecting the optimal MMM materials. It achieves fast computation for the separation of CO2 in MMM.
Hao Wan, Yue Fang, Min Hu, Shuya Guo, Zhiqiang Sui, Xiaoshan Huang, Zili Liu, Yue Zhao, Hong Liang, Yufang Wu, Hanyu Gao, Zhiwei Qiao   +11 more
wiley   +1 more source

Artificial Intelligence and Finance: A bibliometric review on the Trends, Influences, and Research Directions. [PDF]

F1000Res
Roy P, Ghose B, Singh PK, Tyagi PK, Vasudevan A.   +4 more
europepmc   +1 more source

Advancing Investment Frontiers: Industry-grade Deep Reinforcement Learning for Portfolio Optimization

This research paper delves into the application of Deep Reinforcement Learning (DRL) in asset-class agnostic portfolio optimization, integrating industry-grade methodologies with quantitative finance.
Ndikum, Philip, Ndikum, Serge
core  

ROS‐Driven Nanoventilator for MRSA‐Induced Acute Lung Injury Treatment via In Situ Oxygen Supply, Anti‐Inflammation and Immunomodulation

Advanced Science, EarlyView.
A ROS‐driven in situ oxygen supply nanoventilator based on enzyme nanocapsule can convert ROS into O2 through enzyme cascade reaction between SOD and CAT to relieve lung hypoxia, and kill MRSA by releasing vancomycin, which effectively reduces HIF‐1α expression and balances pro‐inflammatory/anti‐inflammatory macrophages ratio, thereby reducing the ...
Zheng Luo, Qi Wang, Xiaotong Fan, Xue Qi Koh, Xian Jun Loh, Caisheng Wu, Zibiao Li, Yun‐Long Wu   +7 more
wiley   +1 more source

Targeting Decidual CD16+ Immune Cells with Exosome‐Based Glucocorticoid Nanoparticles for Miscarriage

Advanced Science, EarlyView.
Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang, Zhinang Yin, Yanqiong Shen, Gang Feng, Fangfang Dai, Dongyong Yang, Zhimin Deng, Jing Yang, Ruizhi Chen, Leifeng Yang, Xian Chen, Qing Sun, Chunyu Huang, Yanxiang Cheng, Hongbing Deng, Lianghui Diao, Longfei Li, Tailang Yin   +17 more
wiley   +1 more source