Results 161 to 170 of about 431,895 (247)

Deep Learning‐Enhanced Hand‐Driven Microfluidic Chip for Multiplexed Nucleic Acid Detection Based on RPA/CRISPR

open access: yesAdvanced Science, EarlyView.
Efficient R‐CHIP HR‐HPV Screening System: The R‐CHIP system utilizes the RPA/CRISPR method, a hand‐driven centrifugal microfluidic device, a smartphone micro‐imaging system, and the ResNet‐18 deep‐learning algorithm to simplify the sample detection process, ensure accurate results, and reduce costs.
Tao Xu   +11 more
wiley   +1 more source

Identification of Tumor‐Specific Surface Proteins Enables Quantification of Extracellular Vesicle Subtypes for Early Detection of Pancreatic Ductal Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) extracellular vesicle (EV) surface protein assay operates via a two‐step workflow – Step 1: Click chemistry‐mediated enrichment of PDAC EVs by EV Click Beads, in the presence of one of the three trans‐cyclooctene‐grafted PDAC EV‐specific antibodies; Step 2: Quantification of the enriched PDAC EVs by reverse ...
Chen Zhao   +27 more
wiley   +1 more source

Noninvasive Assessment of β‐Secretase Activity Through Click Chemistry‐Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
This study presents the NEV β‐secretase activity assay, a groundbreaking method for noninvasive evaluation of β‐secretase activity in Alzheimer's disease (AD) patients, enabling the generation of individualized β‐secretase activity profiles.
Hyoyong Kim   +19 more
wiley   +1 more source

M6A Modified miR‐31‐5p Suppresses M1 Macrophage Polarization and Autoimmune Dry Eye by Targeting P2RX7

open access: yesAdvanced Science, EarlyView.
The upregulation of FTO in autoimmune dry eye suppresses the recognition of pri‐miR‐31 by DGCR8, thereby inhibiting the maturation of miR‐31‐5p and reducing its inhibitory effect on the target gene P2RX7. The activation of P2RX7 subsequently triggers the p38 MAPK signaling pathway and increases the level of M1‐related genes, thus exacerbating the ...
Lu Zhao   +10 more
wiley   +1 more source

RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy

open access: yesAdvanced Science, EarlyView.
RAB3B is unveiled as a prominent oncogenic regulator in chordoma, which can block the DUSP12‐mediated dephosphorylation of p‐S6 (S235/236). The combination of RAB3B and p‐S6 indicates a good prognostic value and predicts mTORC1 inhibitors response for chordoma patients.
Jianxuan Gao   +15 more
wiley   +1 more source

Prevention of unplanned extubation in neonatal patients: Protocol for a systematic review and meta-analysis. [PDF]

open access: yesPLoS One
Pontes LCF   +6 more
europepmc   +1 more source

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