Results 201 to 210 of about 431,895 (247)

Rational Design and Organoid‐Based Evaluation of a Cocktail CAR‐γδ T Cell Therapy for Heterogeneous Glioblastoma

open access: yesAdvanced Science, EarlyView.
A novel “prof” cocktail therapy is designed. It screens antigens, selects personalized antigen panels, engineers optimized CAR‐Vδ1 T cells, and tests in patient‐derived GBM organoids, offering hope for effective CAR‐T drugs against heterogeneous solid tumors. Abstract Various challenges, including tumor heterogeneity and inadequate T cell infiltration,
Guidong Zhu   +12 more
wiley   +1 more source

The Dynamic Landscape of 3′‐UTR Alternative Polyadenylation Across Mouse Fetal Development and Anatomy

open access: yesAdvanced Science, EarlyView.
This work maps 3′‐UTR APA across mouse fetal development and tissues, identifying conserved sequence determinants that influence pAS choice. In fetal brain tissues, complex APA dynamics during development are potentially regulated by RBPs like Rbm38, which restrict distal pAS usage.
Qin Wang, Xin Chen, Xiao‐Ou Zhang
wiley   +1 more source

Low‐Coordination Configuration Single‐Atom Manganese Nanozymes for NIR‐Imaging‐Oriented Efficient Catalytic Oncotherapy

open access: yesAdvanced Science, EarlyView.
The manuscript designs a type of SA Mn‐CDs with low coordination Mn‐N2 configuration hydrothermally synthesized by chelating manganese atoms with ethylenediamine tetraacetic acid. SA Mn‐CDs not only have more active sites at the atomic level for high efficiently peroxidase‐like activity but also show excellent fluorescent ability at the cellular and ...
Peiwei Jin   +8 more
wiley   +1 more source

Dynamic Molecular Cocrystals with Alkyl Chain Dependent Thermosalient Phase Transitions

open access: yesAdvanced Science, EarlyView.
A series of cocrystals containing 5‐fluorocytosine and fatty acids with varying alkyl chain lengths are synthesized, demonstrating a systematic modulation of thermosalient phase transition temperatures across a broad range (≈100 K). This study reveals a linear correlation between interlayer hydrophobic interactions and transition temperatures, offering
Jiantao Meng   +4 more
wiley   +1 more source

Health insurance premium in Colombia for 2025: a strictly political-ideological decision without technical-scientific arguments? [PDF]

open access: yesHealth Econ Rev
Espinosa O   +5 more
europepmc   +1 more source

Ohmic Response in BiFeO3 Domain Walls by Submicron‐Scale Four‐Point Probe Resistance Measurements

open access: yesAdvanced Electronic Materials, EarlyView.
Lateral transport measurements of multiferroic domain walls (DWs) in BiFeO3 thin films employing a novel, lithography‐free method are presented. Using a submicron‐scale multi‐point probe (MPP), ohmic DW conduction behavior is demonstrated, including the first collinear, four‐point resistivity value of a single DW, free of contact resistances.
Jan L. Rieck   +8 more
wiley   +1 more source

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