Results 191 to 200 of about 7,425,705 (296)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Age-dependent shaping of the social environment in a long-lived seabird: a quantitative genetic approach. [PDF]

Philos Trans R Soc Lond B Biol Sci
Moiron M, Bouwhuis S.
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

MPH: fast REML for large-scale genome partitioning of quantitative genetic variation. [PDF]

Bioinformatics
Jiang J.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Correction: Simulation of functional additive and non-additive genetic effects using statistical estimates from quantitative genetic models. [PDF]

Heredity (Edinb)
Chu TT, Kristensen PS, Jensen J.
europepmc   +1 more source

Retrospective Quantitative Genetic Analysis and Genomic Prediction of Global Wheat Yields. [PDF]

Front Plant Sci, 2020
Juliana P, Singh RP, Braun HJ, Huerta-Espino J, Crespo-Herrera L, Payne T, Poland J, Shrestha S, Kumar U, Joshi AK, Imtiaz M, Rahman MM, Toledo FH.   +12 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Population structure in Daphnia obtusa: quantitative genetic and allozymic variation.

Genetics, 1993
K. Spitze
semanticscholar   +1 more source

Simulation of functional additive and non-additive genetic effects using statistical estimates from quantitative genetic models. [PDF]

Heredity (Edinb)
Chu TT, Kristensen PS, Jensen J.
europepmc   +1 more source